표면 항원 음성인 건강 검진 수진자와 만성 음주자에서 B형 간염 바이러스 잠재 감염Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen
- Other Titles
- Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen
- Authors
- 오성남; 연종은; 한우식; 최도원; 김지현; 김연호; 박종재; 김재선; 변관수; 박영태
- Issue Date
- 2008
- Publisher
- 대한내과학회
- Keywords
- Alcoholism; Hepatitis B virus; Occult infection; 만성 B형 간염; 잠재 감염; 만성 음주; Alcoholism; Hepatitis B virus; Occult infection
- Citation
- 대한내과학회지, v.75, no.5, pp.539 - 545
- Indexed
- KCI
- Journal Title
- 대한내과학회지
- Volume
- 75
- Number
- 5
- Start Page
- 539
- End Page
- 545
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124867
- ISSN
- 1738-9364
- Abstract
- Backgrounds/Aims: Hepatitis B virus (HBV) infection and chronic alcoholism are major risk factors for chronic liver disease in Korea.
Methods: We investigated the prevalence of occult HBV infection in 198 non-alcoholic (group I) and 85 chronic alcoholic subjects (group II), none of whom showed the hepatitis B surface antigen (HBsAg). Among chronic alcoholics, 25 patients showed cirrhosis. Using serum samples stored at -70℃, liver enzymes, anti-Hbs, and IgG anti-HBc were measured via EIA and serum HBV DNA was quantified via real time PCR.
Results: IgG anti-HBc seropositivity, an indicator of past infection, was higher in group II (64.7%) than in group I (43.4%; p<0.01). Eleven of 283 patients (3.2%) were seropositive for HBV DNA, indicating occult infection, but this value did not differ between groups (group I: 3.5%, 7/198; group II: 4.7%, 4/85; p=0.64). In group II, HBV DNA seropositivity was higher in cirrhotic patients (12%, 3/25) than in non-cirrhotic alcoholic liver disease (1.7%, 1/60; p=0.074).
Conclusions: Past HBV infection was more prevalent in alcoholics than non-alcoholics, but the prevalence of occult HBV infection did not differ between groups. However, alcoholics with cirrhosis tended to show a higher prevalence of occult HBV infection. (Korean J Med 75:539-545, 2008)
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