초발 주요우울장애 환자의 우울 삽화 및 관해 상태에서 신경인지기능 결함 비교

Abstract

Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) on depressed state and 2) the changes of neuropsychological dysfunctions at depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who werediagnosed and classified by DSM-IV and SCID-IV interview were participated in this study. The psychopathology was measured using Hamilton rating scale for depression (HAM-D) and Brief Psychiatric Rating Scale (BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist usingKorean version of Memory Assessment Scale (K-MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions at remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of K-MAS, total errors of WCST, response time of Vigilance and response time at Yes response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in patients group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved excepting for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.