형태 계측학적 분석과 ThinPrep®액상 소변세포검사를 이용한 악성 요로상피 세포 검출Detecting Malignant Urothelial Cells by Morphometric Analysis of ThinPrep®Liquid-based Urine Cytology Specimens
- Other Titles
- Detecting Malignant Urothelial Cells by Morphometric Analysis of ThinPrep®Liquid-based Urine Cytology Specimens
- Authors
- 김한겸; 이영석; 정회선; 이상호; 김현철; 김애리; 김인선; 신봉경
- Issue Date
- 2008
- Publisher
- 대한세포병리학회
- Keywords
- Liquid-based urine cytology; Urothelial carcinoma; Cytomorphometric analysis; Digital image analysis; Nuclear-to-cytoplasmic ratio.
- Citation
- 대한세포병리학회지, v.19, no.2, pp.136 - 143
- Indexed
- KCI
OTHER
- Journal Title
- 대한세포병리학회지
- Volume
- 19
- Number
- 2
- Start Page
- 136
- End Page
- 143
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124913
- ISSN
- 1017-0391
- Abstract
- Urothelial carcinoma accounts for 90% of all the cases of bladder
cancer. Although many cases can be easily managed by local excision,
urothelial carcinoma rather frequently recurs, tends to progress to
muscle invasion, and requires regular follow-ups. Urine cytology is a
main approach for the follow-up of bladder tumors. It is noninvasive,
but it has low sensitivity of around 50% with using the conventional
cytospin preparation. Liquid-based cytology (LBC) has been developed
as a replacement for the conventional technique. We compared
the cytomorphometric parameters of ThinPrep® and cytospin preparation
urine cytology to see whether there are definite differences
between the two methods and which technique allows malignant cells
to be more effectively discriminated from benign cells. The nuclear-tocytoplasmic
ratio value, as measured by digital image analysis, was
efficient for differentiating malignant and benign urothelial cells, and
this was irrespective of the preparation method and the tumor grade.
Neither the ThinPrep® nor the conventional preparation cytology was
definitely superior for distinguishing malignant cells from benign cells
by cytomorphometric analysis of the adequately preserved cells.
However, the ThinPrep® preparation showed significant advantages
when considering the better preservation and cellularity with a clear
background.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.