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Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer

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dc.contributor.author김대식-
dc.contributor.author성재숙-
dc.contributor.author신은순-
dc.contributor.author유정선-
dc.contributor.author최인근-
dc.contributor.author박경화-
dc.contributor.author박용-
dc.contributor.author김의배-
dc.contributor.author박세종-
dc.contributor.author김열홍-
dc.date.accessioned2021-09-09T14:57:49Z-
dc.date.available2021-09-09T14:57:49Z-
dc.date.issued2008-
dc.identifier.issn1598-2998-
dc.identifier.issn2005-9256-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/125071-
dc.description.abstractPurpose: The expression of the PIM-1 gene, which is a proto-oncogene that encodes a serine/threonine kinase, is associated with multiple cellular functions such as proliferation, differentiation, apoptosis and tumorigenesis. In particular, several studies have reported that the PIM-1 gene is associated with the development of lymphoma, leukemia and prostate cancer. Therefore, this study was conducted to evaluate the association between the single nucleotide polymorphisms in the PIM-1 gene and the risk of lung cancer occurrence in the Korean population. Materials and Methods: To evaluate the role of the PIM-1 gene in the development of lung cancer, the genotypes of the PIM-1 gene were determined in 408 lung cancer patients and 410 normal subjects. Results: We found that the T-C-T-C haplotypes of the PIM-1 gene (−1196 T>C, IVS4 +55 T>C, IVS4 +1416 T>A and +3684 C>A) were associated with an increased risk of lung cancer [adjusted odds ratio (aOR): 3.98; 95% CI: 1.24∼12.75, p-value: 0.020]. In particular, these haplotypes showed an increased risk of lung cancer in males (aOR: 5.67; 95% CI: 1.32∼24.30, p-value: 0.019) and smokers (aOR: 7.82; 95% CI: 1.75∼34.98, p-value: 0.007). Conclusions: The present results suggest that the T-C-T-C haplotype of the PIM-1 gene could influence the risk of developing smoking-related lung cancer in the Korean population. Additional functional studies with an larger sample sized analysis are warranted to reconfirm our findings.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisher대한암학회-
dc.titleAssociation of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer-
dc.title.alternativeAssociation of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.bibliographicCitationCancer Research and Treatment, v.40, no.4, pp 190 - 196-
dc.citation.titleCancer Research and Treatment-
dc.citation.volume40-
dc.citation.number4-
dc.citation.startPage190-
dc.citation.endPage196-
dc.identifier.kciidART001299962-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasskci-
dc.subject.keywordAuthorPIM-1-
dc.subject.keywordAuthorPIM-
dc.subject.keywordAuthorSingle Nucleotide Polymorphism-
dc.subject.keywordAuthorSNP-
dc.subject.keywordAuthorLung neoplasms-
dc.subject.keywordAuthorOncogenes-
dc.subject.keywordAuthorHaplotypes-
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