MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, U.-H. | - |
dc.contributor.author | Jae, H.L. | - |
dc.contributor.author | Kim, H.-J. | - |
dc.contributor.author | Wu, W. | - |
dc.contributor.author | Jin, S. | - |
dc.contributor.author | Xu, H. | - |
dc.contributor.author | Li, J.-D. | - |
dc.date.accessioned | 2021-09-09T15:50:47Z | - |
dc.date.available | 2021-09-09T15:50:47Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125322 | - |
dc.description.abstract | Mucosal epithelial cells in the respiratory tract act as the first line of host innate defense against inhaled microbes by producing a range of molecules for clearance. In particular, epithelial mucins facilitate the mucociliary clearance by physically trapping the inhaled microbes. Up-regulation of mucin production thus represents an important host innate defense response against invading microbes. Excess mucin production, however, overwhelms the mucociliary clearance, resulting in defective mucosal defenses. Thus, tight regulation of mucin production is critical for maintaining an appropriate balance between beneficial and detrimental outcomes. Among various mechanisms, negative regulation plays an important role in tightly regulating mucin production. Here we show that the PAK4-JNK signaling pathway acted as a negative regulator for Streptococcus pneumoniae pneumolysin-induced MUC5AC mucin transcription. Moreover pneumolysin also selectively induced expression of MKP1 via a TLR4-dependent MyD88-TRAF6-ERK signaling pathway, which inhibited the PAK4-JNK signaling pathway, thereby leading to up-regulation of MUC5AC mucin production to maintain effective mucosal protection against S. pneumoniae infection. These studies provide novel insights into the molecular mechanisms underlying the tight regulation of mucin overproduction in the pathogenesis of airway infectious diseases and may lead to development of new therapeutic strategies. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | Planning | - |
dc.subject | Strategic planning | - |
dc.subject | Epithelial cells | - |
dc.subject | Infectious diseases | - |
dc.subject | Innate defenses | - |
dc.subject | Molecular mechanisms | - |
dc.subject | Mucociliary clearances | - |
dc.subject | Negative regulators | - |
dc.subject | Respiratory tracts | - |
dc.subject | Signaling pathways | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Signaling | - |
dc.subject | mitogen activated protein kinase phosphatase | - |
dc.subject | mucin 5AC | - |
dc.subject | p21 activated kinase 4 | - |
dc.subject | pneumolysin | - |
dc.subject | stress activated protein kinase | - |
dc.subject | article | - |
dc.subject | bacterial strain | - |
dc.subject | bacterium culture | - |
dc.subject | enzyme inhibition | - |
dc.subject | genetic transcription | - |
dc.subject | innate immunity | - |
dc.subject | nonhuman | - |
dc.subject | priority journal | - |
dc.subject | protein expression | - |
dc.subject | protein purification | - |
dc.subject | protein secretion | - |
dc.subject | respiratory tract infection | - |
dc.subject | signal transduction | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | upregulation | - |
dc.subject | Animals | - |
dc.subject | Bacterial Proteins | - |
dc.subject | Dual Specificity Phosphatase 1 | - |
dc.subject | Hela Cells | - |
dc.subject | Humans | - |
dc.subject | Immunity, Innate | - |
dc.subject | Immunity, Mucosal | - |
dc.subject | MAP Kinase Kinase 4 | - |
dc.subject | Mice | - |
dc.subject | Mice, Mutant Strains | - |
dc.subject | Mucin 5AC | - |
dc.subject | Myeloid Differentiation Factor 88 | - |
dc.subject | p21-Activated Kinases | - |
dc.subject | Pneumococcal Infections | - |
dc.subject | Respiratory Mucosa | - |
dc.subject | Signal Transduction | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Streptolysins | - |
dc.subject | TNF Receptor-Associated Factor 6 | - |
dc.subject | Toll-Like Receptor 4 | - |
dc.subject | Transcription, Genetic | - |
dc.subject | Up-Regulation | - |
dc.subject | Streptococcus pneumoniae | - |
dc.title | MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ha, U.-H. | - |
dc.identifier.doi | 10.1074/jbc.M802519200 | - |
dc.identifier.scopusid | 2-s2.0-57649183349 | - |
dc.identifier.bibliographicCitation | Journal of Biological Chemistry, v.283, no.45, pp.30624 - 30631 | - |
dc.relation.isPartOf | Journal of Biological Chemistry | - |
dc.citation.title | Journal of Biological Chemistry | - |
dc.citation.volume | 283 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 30624 | - |
dc.citation.endPage | 30631 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | Planning | - |
dc.subject.keywordPlus | Strategic planning | - |
dc.subject.keywordPlus | Epithelial cells | - |
dc.subject.keywordPlus | Infectious diseases | - |
dc.subject.keywordPlus | Innate defenses | - |
dc.subject.keywordPlus | Molecular mechanisms | - |
dc.subject.keywordPlus | Mucociliary clearances | - |
dc.subject.keywordPlus | Negative regulators | - |
dc.subject.keywordPlus | Respiratory tracts | - |
dc.subject.keywordPlus | Signaling pathways | - |
dc.subject.keywordPlus | Streptococcus pneumoniae | - |
dc.subject.keywordPlus | Signaling | - |
dc.subject.keywordPlus | mitogen activated protein kinase phosphatase | - |
dc.subject.keywordPlus | mucin 5AC | - |
dc.subject.keywordPlus | p21 activated kinase 4 | - |
dc.subject.keywordPlus | pneumolysin | - |
dc.subject.keywordPlus | stress activated protein kinase | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bacterial strain | - |
dc.subject.keywordPlus | bacterium culture | - |
dc.subject.keywordPlus | enzyme inhibition | - |
dc.subject.keywordPlus | genetic transcription | - |
dc.subject.keywordPlus | innate immunity | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein purification | - |
dc.subject.keywordPlus | protein secretion | - |
dc.subject.keywordPlus | respiratory tract infection | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | Streptococcus pneumoniae | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Bacterial Proteins | - |
dc.subject.keywordPlus | Dual Specificity Phosphatase 1 | - |
dc.subject.keywordPlus | Hela Cells | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Immunity, Innate | - |
dc.subject.keywordPlus | Immunity, Mucosal | - |
dc.subject.keywordPlus | MAP Kinase Kinase 4 | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Mutant Strains | - |
dc.subject.keywordPlus | Mucin 5AC | - |
dc.subject.keywordPlus | Myeloid Differentiation Factor 88 | - |
dc.subject.keywordPlus | p21-Activated Kinases | - |
dc.subject.keywordPlus | Pneumococcal Infections | - |
dc.subject.keywordPlus | Respiratory Mucosa | - |
dc.subject.keywordPlus | Signal Transduction | - |
dc.subject.keywordPlus | Streptococcus pneumoniae | - |
dc.subject.keywordPlus | Streptolysins | - |
dc.subject.keywordPlus | TNF Receptor-Associated Factor 6 | - |
dc.subject.keywordPlus | Toll-Like Receptor 4 | - |
dc.subject.keywordPlus | Transcription, Genetic | - |
dc.subject.keywordPlus | Up-Regulation | - |
dc.subject.keywordPlus | Streptococcus pneumoniae | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.