Impaired metabolomics of sulfur-containing substances in rats acutely treated with carbon tetrachloride
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, S.J. | - |
dc.contributor.author | Kwon, D.Y. | - |
dc.contributor.author | Choi, K.H. | - |
dc.contributor.author | Choi, D.W. | - |
dc.contributor.author | Kim, Y.C. | - |
dc.date.accessioned | 2021-09-09T15:53:25Z | - |
dc.date.available | 2021-09-09T15:53:25Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125336 | - |
dc.description.abstract | Impairment of hepatic metabolism of sulfur-containing amino acids has been known to be linked with induction of liver injury. We determined the early changes in the transsulfuration reactions in liver of rats challenged with a toxic dose of CCl4 (2 mmol/kg, ip). Both hepatic methionine concentration and methionine adenosyltransferase activity were increased, but S-adenosylmethionine level did not change. Hepatic cysteine was increased significantly from 4 h after CCl4 treatment. Glutathione (GSH) concentration in liver was elevated in 4̃8 h and then returned to normal in accordance with the changes in glutamate cysteine ligase activity. Cysteine dioxygenase activity and hypotaurine concentration were also elevated from 4 h after the treatment. However, plasma GSH concentration was increased progressively, reaching a level at least several fold greater than normal in 24 h. γ-Glutamyltransferase activity in kidney or liver was not altered by CCl4, suggesting that the increase in plasma GSH could not be attributed to a failure of GSH cycling. The results indicate that acute liver injury induced by CCl4 is accompanied with extensive alterations in the metabolomics of sulfurcontaining amino acids and related substances. The major metabolites and products of the transsulfuration pathway, including methionine, cysteine, hypotaurine, and GSH, are all increased in liver and plasma. The physiological significance of the change in the metabolomics of sulfur-containing substances and its role in the induction of liver injury need to be explored in future studies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.title | Impaired metabolomics of sulfur-containing substances in rats acutely treated with carbon tetrachloride | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, D.W. | - |
dc.identifier.doi | 10.5487/TR.2008.24.4.281 | - |
dc.identifier.scopusid | 2-s2.0-84880643067 | - |
dc.identifier.bibliographicCitation | Toxicological Research, v.24, no.4, pp.281 - 287 | - |
dc.relation.isPartOf | Toxicological Research | - |
dc.citation.title | Toxicological Research | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 287 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001293673 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Carbon tetrachloride | - |
dc.subject.keywordAuthor | Glutathione | - |
dc.subject.keywordAuthor | S-adenosylmethionine | - |
dc.subject.keywordAuthor | Taurine | - |
dc.subject.keywordAuthor | Transsulfuration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.