IL-1 beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H pylori eradication in gastroduodenal phenotypes
DC Field | Value | Language |
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dc.contributor.author | Chang, Young Woon | - |
dc.contributor.author | Oh, Hyoung-Chul | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Hwangbo, Young | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Lee, Hyo Jung | - |
dc.contributor.author | Joo, Kwang Ro | - |
dc.contributor.author | Dong, Seok Ho | - |
dc.contributor.author | Kim, Sung Soo | - |
dc.contributor.author | Kim, Hyo Jong | - |
dc.contributor.author | Kim, Byung Ho | - |
dc.contributor.author | Chang, Rin | - |
dc.date.accessioned | 2021-09-09T16:26:04Z | - |
dc.date.available | 2021-09-09T16:26:04Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125519 | - |
dc.description.abstract | Objective. Relations between host genetic factors and clinical outcomes of Helicobacter pylori infection are variable among ethnicities. The aim of this study was to examine gastric mucosal cytokines, matrix metalloproteinase 3 (MMP-3), and serum pepsinogen levels before and after eradication of H. pylori according to IL-1B genotypes and benign gastroduodenal phenotypes in a Korean population. Material and methods. A total of 349 Koreans including H. pylori-infected subjects (n=230) and H. pylori-negative controls (n=119) were enrolled. The former subjects were classified into groups according to the presence of non-atrophic gastritis (n=74), atrophic gastritis (n=56), gastric ulcer (n=37), and duodenal ulcer (n=63). IL-1B polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Gastric mucosal IL-1 beta, IL-8, and MMP-3, and serum pepsinogen I and II levels were measured by ELISA and radioimmunoassay, respectively. Results. There were no significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and CC/TT) frequencies among the H. pylori-positive and -negative groups. The genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. pylori-infected atrophic gastritis exhibited significantly higher basal levels of cytokines and a lower pepsinogen I/II ratio than those of other groups. Following H. pylori eradication, inflammatory cytokines significantly decreased and the pepsinogen I/II ratio increased in all groups. Conclusions. Mucosal inflammatory cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal phenotypes but not to IL-1B genotypes. Eradication of H. pylori can reduce mucosal inflammation and restore pepsinogen secretion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject | INTERLEUKIN-1 POLYMORPHISMS | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | PATHOGENICITY ISLAND | - |
dc.subject | INCREASED RISK | - |
dc.subject | FACTOR-ALPHA | - |
dc.subject | INFECTION | - |
dc.subject | INFLAMMATION | - |
dc.subject | GENE | - |
dc.subject | CYTOKINE | - |
dc.title | IL-1 beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H pylori eradication in gastroduodenal phenotypes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae Won | - |
dc.identifier.doi | 10.1080/00365520802130209 | - |
dc.identifier.scopusid | 2-s2.0-52149085917 | - |
dc.identifier.wosid | 000259318200005 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.43, no.10, pp.1184 - 1193 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1184 | - |
dc.citation.endPage | 1193 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | INTERLEUKIN-1 POLYMORPHISMS | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | PATHOGENICITY ISLAND | - |
dc.subject.keywordPlus | INCREASED RISK | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | gastroduodenal phenotypes | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | IL-1B genotypes | - |
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