Hyperthermia on mesenchymal stem cells (MSCs) can sensitize tumor cells to undergo cell death
DC Field | Value | Language |
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dc.contributor.author | Park, Ho | - |
dc.contributor.author | Cho, Jung-Ah | - |
dc.contributor.author | Kim, Suel-Kee | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Lee, Sang-Hoon | - |
dc.date.accessioned | 2021-09-09T16:26:54Z | - |
dc.date.available | 2021-09-09T16:26:54Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0265-6736 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125523 | - |
dc.description.abstract | Hyperthermia, the procedure of raising the temperature of tumor-loaded tissue to 40-43C, has been applied to various established cancer treatments. Although the mechanism of hyperthermia in cancer treatment is well-known, there are few or no studies regarding the effect of hyperthermia on the tumor-supportive stroma. Mesenchymal stem cells (MSCs) display the potential for differentiation into various tissues. MSCs are also reported to play a role as potential precursors for tumor stroma in providing a favorable environment for tumor progression. Here, we investigated the effects of hyperthermia-treated MSCs on the viability and growth of cancer cells. Culture supernatants from non-shocked or heat-shocked MSCs (NS-MSCs or HS-MSCs) were added to MCF7 cells. Morphological analysis and cell proliferation assay showed the reduced viability and growth of MCF7 cells by addition of culture medium conditioned by HS-MSCs. Additionally, exposure to the conditioned medium by HS-MSCs induced cell cycle arrest at G2/M phase, increased MHC class I, Fas receptor, and TNF-R expressions, and decreased MDR1 expression in the MCF7 cells. In particular, the conditioned medium of HS-MSCs accelerated the inhibition of tumor cell growth by several chemotherapeutic drugs. These data present new aspects of hyperthermia in cancer treatment, suggesting that hyperthermia can enable tumor stroma provide a sensitizing environment for tumor cells to undergo cell death. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | PROSTATE-CANCER PROGRESSION | - |
dc.subject | BONE-MARROW | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IN-VIVO | - |
dc.subject | DELIVERY VEHICLES | - |
dc.subject | BREAST-CANCER | - |
dc.subject | GROWTH | - |
dc.subject | APOPTOSIS | - |
dc.subject | STROMA | - |
dc.subject | MICROENVIRONMENT | - |
dc.title | Hyperthermia on mesenchymal stem cells (MSCs) can sensitize tumor cells to undergo cell death | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Hoon | - |
dc.identifier.doi | 10.1080/02656730802253117 | - |
dc.identifier.scopusid | 2-s2.0-57649180522 | - |
dc.identifier.wosid | 000261508600004 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HYPERTHERMIA, v.24, no.8, pp.638 - 648 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HYPERTHERMIA | - |
dc.citation.title | INTERNATIONAL JOURNAL OF HYPERTHERMIA | - |
dc.citation.volume | 24 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 638 | - |
dc.citation.endPage | 648 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | PROSTATE-CANCER PROGRESSION | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DELIVERY VEHICLES | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | STROMA | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | tumor stroma | - |
dc.subject.keywordAuthor | hyperthermia | - |
dc.subject.keywordAuthor | cancer therapy | - |
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