Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Je Hyeong | - |
dc.contributor.author | Suk, Min Hyun | - |
dc.contributor.author | Yoon, Dae Wui | - |
dc.contributor.author | Kim, Hye Young | - |
dc.contributor.author | Jung, Ki Hwan | - |
dc.contributor.author | Kang, Eun Hae | - |
dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Suh, In Bum | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Shim, Jae Jeong | - |
dc.contributor.author | In, Kwang Ho | - |
dc.contributor.author | Yoo, Se Hwa | - |
dc.contributor.author | Kang, Kyung Ho | - |
dc.date.accessioned | 2021-09-09T16:32:56Z | - |
dc.date.available | 2021-09-09T16:32:56Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1466-609X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125554 | - |
dc.description.abstract | Introduction Poly (ADP-ribose) polymerase ( PARP) participates in inflammation by cellular necrosis and the nuclear factor-kappa-B (NF-kappa B)-dependent transcription. The purpose of this study was to examine the roles of PARP in ventilator-induced lung injury (VILI) in normal mice lung. Methods Male C57BL/6 mice were divided into four groups: sham tracheostomized (sham), lung-protective ventilation (LPV), VILI, and VILI with PARP inhibitor PJ34 pretreatment (PJ34+VILI) groups. Mechanical ventilation (MV) settings were peak inspiratory pressure (PIP) 15 cm H2O + positive end-expiratory pressure (PEEP) 3 cm H2O + 90 breaths per minute for the LPV group and PIP 40 cm H2O + PEEP 0 cm H2O + 90 breaths per minute for the VILI and PJ34+ VILI groups. After 2 hours of MV, acute lung injury (ALI) score, wet-to-dry (W/D) weight ratio, PARP activity, and dynamic compliance (CD) were recorded. Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), myeloperoxidase (MPO) activity, and nitrite/nitrate (NOX) in the bronchoalveolar lavage fluid and NF-.B DNA-binding activity in tissue homogenates were measured. Results The VILI group showed higher ALI score, W/D weight ratio, MPO activity, NOX, and concentrations of TNF-alpha and IL-6 along with lower CD than the sham and LPV groups (P < 0.05). In the PJ34+ VILI group, PJ34 pretreatment improved all histopathologic ALI, inflammatory profiles, and pulmonary dynamics (P < 0.05). NF-kappa B activity was increased in the VILI group as compared with the sham and LPV groups (P < 0.05) and was decreased in the PJ34+ VILI group as compared with the VILI group (P = 0.009). Changes in all parameters were closely correlated with the PARP activity (P < 0.05). Conclusion Overactivation of PARP plays an important role in the inflammatory and transcriptional pathogenesis of VILI, and PARP inhibition has potentially beneficial effects on the prevention and treatment of VILI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject | DEPENDENT GENE-EXPRESSION | - |
dc.subject | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | SYNTHETASE INHIBITION | - |
dc.subject | ISCHEMIA-REPERFUSION | - |
dc.subject | ACTIVATION | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | AUTOMODIFICATION | - |
dc.title | Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Je Hyeong | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeub | - |
dc.contributor.affiliatedAuthor | In, Kwang Ho | - |
dc.contributor.affiliatedAuthor | Yoo, Se Hwa | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Ho | - |
dc.identifier.doi | 10.1186/cc6995 | - |
dc.identifier.scopusid | 2-s2.0-51349090137 | - |
dc.identifier.wosid | 000260082700024 | - |
dc.identifier.bibliographicCitation | CRITICAL CARE, v.12, no.4 | - |
dc.relation.isPartOf | CRITICAL CARE | - |
dc.citation.title | CRITICAL CARE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject.keywordPlus | DEPENDENT GENE-EXPRESSION | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SYNTHETASE INHIBITION | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | AUTOMODIFICATION | - |
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