Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Song, Jae-Jun | - |
dc.contributor.author | Cho, Jae Gu | - |
dc.contributor.author | Hwang, Soon-Jae | - |
dc.contributor.author | Cho, Chang Gun | - |
dc.contributor.author | Park, Seok-Won | - |
dc.contributor.author | Chae, Sung-Won | - |
dc.date.accessioned | 2021-09-09T16:36:52Z | - |
dc.date.available | 2021-09-09T16:36:52Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0001-6489 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125572 | - |
dc.description.abstract | Conclusions. The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)- expression and interleukin (IL)-8 production. The anti-inflammatory effect of CAPE is possibly through the inhibition of nuclear factor (NF)-B via the suppression of inhibitor-B- (IB-) degradation. Objectives. CAPE is a biologically active component of propolis, a resinous material obtained from bee hives, which originates from conifer bark. The effect of CAPE on lipopolysaccharide (LPS)-induced inflammatory reactions is not known. The aim of this study was to evaluate the anti-inflammatory effect of CAPE on cultured human middle ear epithelial cells (HMEECs). Materials and methods. The effect of CAPE on LPS-induced TNF- expression was evaluated in HMEECs by real-time reverse transcription polymerase chain reaction (RT-PCR). LPS-induced IL-8 production was determined by enzyme-linked immunosorbent assay (ELISA), and LPS-induced IB- degradation was followed by Western blot analysis. Results. CAPE significantly inhibited LPS-induced up-regulation of TNF- in a dose-dependent manner. IL-8 production by LPS was significantly suppressed by the CAPE pretreatment. Furthermore, LPS-induced IB- degradation was suppressed by the CAPE pretreatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | OTITIS-MEDIA | - |
dc.subject | NUCLEAR-FACTOR | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | ACTIVATION | - |
dc.subject | EFFUSIONS | - |
dc.title | Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Soon-Jae | - |
dc.contributor.affiliatedAuthor | Chae, Sung-Won | - |
dc.identifier.doi | 10.1080/00016480801947082 | - |
dc.identifier.scopusid | 2-s2.0-57349138897 | - |
dc.identifier.wosid | 000260772700004 | - |
dc.identifier.bibliographicCitation | ACTA OTO-LARYNGOLOGICA, v.128, no.12, pp.1303 - 1307 | - |
dc.relation.isPartOf | ACTA OTO-LARYNGOLOGICA | - |
dc.citation.title | ACTA OTO-LARYNGOLOGICA | - |
dc.citation.volume | 128 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1303 | - |
dc.citation.endPage | 1307 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | OTITIS-MEDIA | - |
dc.subject.keywordPlus | NUCLEAR-FACTOR | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EFFUSIONS | - |
dc.subject.keywordAuthor | Caffeic acid phenethyl ester | - |
dc.subject.keywordAuthor | otitis media | - |
dc.subject.keywordAuthor | NF-B | - |
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