Aberrant promoter CpG islands methylation of tumor suppressor genes in cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Uhm, Kyung-Ok | - |
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Lee, Yun Mi | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Park, Young-Nyun | - |
dc.contributor.author | Park, Sun-Hwa | - |
dc.date.accessioned | 2021-09-09T16:38:35Z | - |
dc.date.available | 2021-09-09T16:38:35Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0965-0407 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125581 | - |
dc.description.abstract | Aberrant DNA methylation of 5'-CpG islands located within gene promoters has been identified as a mechanism for transcriptional inactivation of tumor suppressor genes. To ascertain the mechanism of gene promoter hypermethylation in cholangiocarcinoma (CC), we investigated promoter methylation status of the candidate genes ID4, DLC-1, and SFRP1 in 41 CCs, 19 adjacent nontumor tissues, and 15 normal liver tissues using methylation-specific PCR (MSP). The frequencies of DNA methylation were: 57.5% (23 of 40) for ID4, 14.3% (5 of 35) for DLC-1, and 63.4% (26 of 41) for SFRP1, respectively. In contrast, a low frequency of methylation was detected in nontumor tissues. In addition, hypermethylated status of these genes was detected in three kinds of CC cell lines. Moreover, the downregulated expression of these genes in these cells was restored by treatment with 5-aza-2'-deoxycytidine, a DNA methyltransferase inhibitor. Taken together, these results suggest that abet-rant DNA methylation may contribute to the tumorigenesis of cholangiocarcinoma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | COGNIZANT COMMUNICATION CORP | - |
dc.subject | EPIGENETIC INACTIVATION | - |
dc.subject | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject | HYPERMETHYLATION | - |
dc.subject | ID4 | - |
dc.subject | FREQUENT | - |
dc.subject | SFRP1 | - |
dc.title | Aberrant promoter CpG islands methylation of tumor suppressor genes in cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.contributor.affiliatedAuthor | Park, Sun-Hwa | - |
dc.identifier.doi | 10.3727/096504008785114110 | - |
dc.identifier.scopusid | 2-s2.0-51049089912 | - |
dc.identifier.wosid | 000258114100001 | - |
dc.identifier.bibliographicCitation | ONCOLOGY RESEARCH, v.17, no.4, pp.151 - 157 | - |
dc.relation.isPartOf | ONCOLOGY RESEARCH | - |
dc.citation.title | ONCOLOGY RESEARCH | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 151 | - |
dc.citation.endPage | 157 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | EPIGENETIC INACTIVATION | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | HYPERMETHYLATION | - |
dc.subject.keywordPlus | ID4 | - |
dc.subject.keywordPlus | FREQUENT | - |
dc.subject.keywordPlus | SFRP1 | - |
dc.subject.keywordAuthor | cholangiocarcinoma | - |
dc.subject.keywordAuthor | hypermethylation | - |
dc.subject.keywordAuthor | methylation-specific PCR | - |
dc.subject.keywordAuthor | tumor suppressor gene | - |
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