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The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions

Authors
Jo, Yong SangPark, Eun HyeKim, Il HwanPark, Soon KwonKim, HyunKim, Hyun TaekChoi, June-Seek
Issue Date
5-12월-2007
Publisher
SOC NEUROSCIENCE
Keywords
prefrontal cortex; CA3; spatial memory; pattern completion; memory retrieval; water maze; c-fos
Citation
JOURNAL OF NEUROSCIENCE, v.27, no.49, pp.13567 - 13578
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE
Volume
27
Number
49
Start Page
13567
End Page
13578
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125646
DOI
10.1523/JNEUROSCI.3589-07.2007
ISSN
0270-6474
Abstract
Brain circuits involved in pattern completion, or retrieval of memory from fragmented cues, were investigated. Using different versions of the Morris water maze, we explored the roles of the CA3 subregion of the hippocampus and the medial prefrontal cortex (mPFC) in spatial memory retrieval under various conditions. In a hidden platform task, both CA3 and mPFC lesions disrupted memory retrieval under partial-cue, but not under full-cue, conditions. For a delayed matching-to-place task, CA3 lesions produced a deficit in both forming and recalling spatial working memory regardless of extramaze cue conditions. In contrast, damage to mPFC impaired memory retrieval only when a fraction of cues was available. To corroborate the lesion study, we examined the expression of the immediate early gene c-fos in mPFC and the hippocampus. After training of spatial reference memory in full-cue conditions for 6 d, the same training procedure in the absence of all cues except one increased the number of Fos-immunoreactive cells in mPFC and CA3. Furthermore, mPFC inactivation with muscimol, a GABA agonist, blocked memory retrieval in the degraded-cue environment. However, mPFC-lesioned animals initially trained in a single-cue environment had no difficulty in retrieving spatial memory when the number of cues was increased, demonstrating that contextual change per se did not impair the behavioral performance of the mPFC-lesioned animals. Together, these findings strongly suggest that pattern completion requires interactions between mPFC and the hippocampus, in which mPFC plays significant roles in retrieving spatial information maintained in the hippocampus for efficient navigation.
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