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Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase

Authors
Hwang, Kyo SeonLee, Sang-MyungEom, KilhoLee, Jeong HoonLee, Yoon-SikPark, Jung HoYoon, Dae SungKim, Tae Song
Issue Date
30-11월-2007
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Keywords
nanomechanics; microcantilever; RNA aptamer; HCV helicase; resonant frequency
Citation
BIOSENSORS & BIOELECTRONICS, v.23, no.4, pp.459 - 465
Indexed
SCIE
SCOPUS
Journal Title
BIOSENSORS & BIOELECTRONICS
Volume
23
Number
4
Start Page
459
End Page
465
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125671
DOI
10.1016/j.bios.2007.05.006
ISSN
0956-5663
Abstract
We report the nanomechanical microcantilevers operated in vibration modes (oscillation) with use of RNA aptamers as receptor molecules for label-free detection of hepatitis C virus (HCV) helicase. The nanomechanical detection principle is that the ligand-receptor binding on the microcantilever surface induces the dynamic response change of microcantilevers. We implemented the label-free detection of HCV helicase in the low concentration as much as 100 pg/ml from measuring the dynamic response change of microcantilevers. Moreover, from the recent studies showing that the ligand-receptor binding generates the surface stress on the microcantilever, we estimate the surface stress, on the oscillating microcantilevers, induced by ligand-receptor binding, i.e. binding between HCV helicase and RNA aptamer. In this article, it is suggested that the oscillating microcantilevers with use of RNA aptamers as receptor molecules may enable one to implement the sensitive label-free detection of very small amount of small-scale proteins. (c) 2007 Elsevier B.V. All rights reserved.
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