Induction of mucosal and systemic immune responses following oral immunization of mice with Lactococcus lactis expressing human papillomavirus type 16 L1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hee-Jeong | - |
dc.contributor.author | Shin, Hye-Jeong | - |
dc.contributor.author | Han, In-Kwon | - |
dc.contributor.author | Jung, Woon-Won | - |
dc.contributor.author | Kim, Young Bong | - |
dc.contributor.author | Sul, Donggeun | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.date.accessioned | 2021-09-09T16:59:58Z | - |
dc.date.available | 2021-09-09T16:59:58Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2007-11-19 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125672 | - |
dc.description.abstract | Human papillomavirus type 16 L1 (HPV16 L1) has shown considerable promise as a parenteral vaccine for prevention of cervical cancers. Here, we report the possibility of oral vaccination for HPV16 L1 using Lactococcus lactis (L. lactis) as a live vector. L. lactis MG1363 was transformed with two types of HPV16 L1-encoding plasmids for intracellular expression or secretion. L. lactis transformed with HPV16 L1 -encoding plasmids retained biochemical lactic acid production capability. The mucosal and systemic immune responses were affected by the cellular location of expressed HPV16 L1 proteins in L. lactis. Serum IgG responses were induced after oral immunizations of L. lactis secreting HPV16 L1. Vaginal IgA immune responses were observed following oral immunization with L. lactis expressing HPV16 L1 in an intracellular form, but not with L. lactis secreting HPV16 L1. Furthermore, induction of HPV16 L1-specific mucosal immune responses was affected by immunization frequency. Six immunizations over 5 weeks were required to induce vaginal immune responses. The levels of HPV 16 L1-specific vaginal IgA were maintained until 12 weeks after the first vaccination. These results suggest the feasibility of L. lactis as an oral vaccine vehicle of HPV16 L1 and demonstrate the importance of cellular loci of expressed antigen for induction of vaginal and systemic immune responses. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | PARTICLE VACCINE | - |
dc.subject | PLASMID DNA | - |
dc.subject | ANTIGEN | - |
dc.subject | INTRANASAL | - |
dc.subject | PROTECTION | - |
dc.subject | TETANUS | - |
dc.subject | IMMUNOGENICITY | - |
dc.subject | EFFICACY | - |
dc.subject | PROTEIN | - |
dc.subject | CANCER | - |
dc.title | Induction of mucosal and systemic immune responses following oral immunization of mice with Lactococcus lactis expressing human papillomavirus type 16 L1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, Donggeun | - |
dc.identifier.doi | 10.1016/j.vaccine.2007.09.024 | - |
dc.identifier.scopusid | 2-s2.0-35448935267 | - |
dc.identifier.wosid | 000251331400008 | - |
dc.identifier.bibliographicCitation | VACCINE, v.25, no.47, pp.8049 - 8057 | - |
dc.relation.isPartOf | VACCINE | - |
dc.citation.title | VACCINE | - |
dc.citation.volume | 25 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 8049 | - |
dc.citation.endPage | 8057 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | PARTICLE VACCINE | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | INTRANASAL | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | TETANUS | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | human papillomavirus | - |
dc.subject.keywordAuthor | Lactococcus lactis | - |
dc.subject.keywordAuthor | oral immunization | - |
dc.subject.keywordAuthor | mucosal immune response | - |
dc.subject.keywordAuthor | oral vaccine vehicle | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.