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Arrayed pH-responsive microvalves controlled by multiphase laminar flow

Authors
Liu, ChenweiPark, Joong YullXu, YugongLee, SangHoon
Issue Date
10월-2007
Publisher
IOP PUBLISHING LTD
Citation
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, v.17, no.10, pp.1985 - 1991
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume
17
Number
10
Start Page
1985
End Page
1991
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125698
DOI
10.1088/0960-1317/17/10/009
ISSN
0960-1317
Abstract
In chemical and biological assays, the synchronized control of multiple valves is very important. Currently there is no control scheme for the use of a large number of valves without adopting bulky peripheral control devices such as pumps or electrical equipment. Therefore, we propose a simple pH-responsive microvalve array system and a new multiplexing technology that, through its reliance on multiphase laminar flow, facilitates the operation of arrayed multiple microvalves. For the fabrication of the microvalve arrays, we have used pH-responsive hydrogel microspheres produced by a microfluidic chip. By incorporating these microspheres inside an arrayed microvalve polydimethylsiloxane (PDMS) platform, we produced pH-responsive arrayed microvalves with 'open' and 'close' operations carried out by the multiphase laminar streams of pH solutions. The constructed arrayed microvalves were adequately controlled by the multiphase pH buffer; the pressure of the pH-buffer solutions controlled the widths of the sample flow. Based on the simplicity and reliability of the operating principles, this new arrayed-valve system will decrease the need for complicated peripheral lines and will remove the need for many solenoid valves, which are currently used for the individual control of arrayed valves.
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