Association between serum testosterone levels and the severity of negative symptoms in male patients with chronic schizophrenia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Young-Hoon | - |
dc.contributor.author | Jung, Sung-Won | - |
dc.contributor.author | Joe, Sook-Haeng | - |
dc.contributor.author | Lee, Chang-Hyun | - |
dc.contributor.author | Jung, Hyun-Gang | - |
dc.contributor.author | Jung, In-Kwa | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Lee, Moon-Su | - |
dc.date.accessioned | 2021-09-09T17:19:48Z | - |
dc.date.available | 2021-09-09T17:19:48Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2007-05 | - |
dc.identifier.issn | 0306-4530 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125776 | - |
dc.description.abstract | Objectives: Dysfunction of the hypothalamic-pituitary-gonadal axis may contribute to the pathophysiology of schizophrenia. Recent neuroendocrinological studies have suggested that gonadal sex hormones, including androgens and estrogen, play a significant role in the pathophysiology of schizophrenia. The purpose of this study was to determine any correlation between negative symptoms and the plasma levels of free testosterone, total testosterone, dehydroepiandrosterone sulfate, estradiol, and prolactin with consideration to depressive symptoms, extrapyramidal symptoms (EPS), and other factors including differences in age, diurnal variation of the serum hormone levels, and body fat composition. Methods: The subjects were 35 male inpatients with chronic schizophrenia aged 20-39 years. The patients' psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). The Calgary Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale (DIEPSS) were also used to exclude the effects of depression or drug-induced movement disorders. Results: The PANSS negative scores had a significant inverse correlation with the serum total and free testosterone levels. The other hormone levels were not correlated with the PANSS negative scores. Moreover, a partial correlation analysis showed an inverse correlation between the PANSS negative subscores and the serum total and free testosterone levels after controlling for the DIEPSS and/or CDSS scores and age. Conclusions: This study indicates that total and free testosterone may play an important rote in the severity of negative symptoms in mate patients with schizophrenia. (C) 2007 Published by Elsevier Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PITUITARY-GONADAL AXIS | - |
dc.subject | BINDING-GLOBULIN | - |
dc.subject | DEHYDROEPIANDROSTERONE-SULFATE | - |
dc.subject | PROLACTIN ELEVATION | - |
dc.subject | STEROID-HORMONES | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | LIFE-STYLE | - |
dc.subject | NORMAL MEN | - |
dc.subject | AGE | - |
dc.subject | DEPRESSION | - |
dc.title | Association between serum testosterone levels and the severity of negative symptoms in male patients with chronic schizophrenia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Young-Hoon | - |
dc.contributor.affiliatedAuthor | Jung, Hyun-Gang | - |
dc.contributor.affiliatedAuthor | Lee, Moon-Su | - |
dc.identifier.doi | 10.1016/j.psyneuen.2007.02.002 | - |
dc.identifier.scopusid | 2-s2.0-34247281469 | - |
dc.identifier.wosid | 000246547700008 | - |
dc.identifier.bibliographicCitation | PSYCHONEUROENDOCRINOLOGY, v.32, no.4, pp.385 - 391 | - |
dc.relation.isPartOf | PSYCHONEUROENDOCRINOLOGY | - |
dc.citation.title | PSYCHONEUROENDOCRINOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 385 | - |
dc.citation.endPage | 391 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | PITUITARY-GONADAL AXIS | - |
dc.subject.keywordPlus | BINDING-GLOBULIN | - |
dc.subject.keywordPlus | DEHYDROEPIANDROSTERONE-SULFATE | - |
dc.subject.keywordPlus | PROLACTIN ELEVATION | - |
dc.subject.keywordPlus | STEROID-HORMONES | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | LIFE-STYLE | - |
dc.subject.keywordPlus | NORMAL MEN | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | negative symptoms | - |
dc.subject.keywordAuthor | testosterone | - |
dc.subject.keywordAuthor | free testosterone | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.