Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
DC Field | Value | Language |
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dc.contributor.author | Bonaca, Marc P. | - |
dc.contributor.author | Bhatt, Deepak L. | - |
dc.contributor.author | Cohen, Marc | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Storey, Robert F. | - |
dc.contributor.author | Jensen, Eva C. | - |
dc.contributor.author | Magnani, Giulia | - |
dc.contributor.author | Bansilal, Sameer | - |
dc.contributor.author | Fish, M. Polly | - |
dc.contributor.author | Im, Kyungah | - |
dc.contributor.author | Bengtsson, Olof | - |
dc.contributor.author | Ophuis, Ton Oude | - |
dc.contributor.author | Budaj, Andrzej | - |
dc.contributor.author | Theroux, Pierre | - |
dc.contributor.author | Ruda, Mikhail | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Goto, Shinya | - |
dc.contributor.author | Spinar, Jindrich | - |
dc.contributor.author | Nicolau, Jose Carlos | - |
dc.contributor.author | Kiss, Robert G. | - |
dc.contributor.author | Murphy, Sabina A. | - |
dc.contributor.author | Wiviott, Stephen D. | - |
dc.contributor.author | Held, Peter | - |
dc.contributor.author | Braunwald, Eugene | - |
dc.contributor.author | Sabatine, Marc S. | - |
dc.contributor.author | Morin, Suzanne | - |
dc.contributor.author | Fish, M. Polly | - |
dc.contributor.author | Dantzer, Emily | - |
dc.contributor.author | Acquilano, Dayle | - |
dc.contributor.author | McGuire, Rachael L. | - |
dc.contributor.author | Gannon, Joseph B. | - |
dc.contributor.author | Gershman, Elaine | - |
dc.contributor.author | Im, KyungAh | - |
dc.contributor.author | Ahlbom, Ann Maxe | - |
dc.contributor.author | Boberg, Barbro | - |
dc.contributor.author | Abola, Maria Teresa | - |
dc.contributor.author | Ardissino, Diego | - |
dc.contributor.author | Aylward, Philip | - |
dc.contributor.author | Budaj, Andrzej | - |
dc.contributor.author | Corbalan, Ramon | - |
dc.contributor.author | Dalby, Anthony | - |
dc.contributor.author | Dellborg, Mikael | - |
dc.contributor.author | Diaz, Rafael | - |
dc.contributor.author | Dimulescu, Doina | - |
dc.contributor.author | Goto, Shinya | - |
dc.contributor.author | Goudev, Assen | - |
dc.contributor.author | Guneri, Sema | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Hu, Dayi | - |
dc.contributor.author | Isaza, Daniel | - |
dc.contributor.author | Kamensky, Gabriel | - |
dc.contributor.author | Kiss, Robert | - |
dc.contributor.author | Kontny, Frederic | - |
dc.contributor.author | Lopez-Sendon, Jose | - |
dc.contributor.author | Medina, Felix | - |
dc.contributor.author | Montalescot, Gilles | - |
dc.contributor.author | Nicolau, Jose | - |
dc.contributor.author | Paolasso, Ernesto | - |
dc.contributor.author | Parkhomenko, Alexander | - |
dc.contributor.author | Ruda, Mikhail | - |
dc.contributor.author | Seung, Ki-Bae | - |
dc.contributor.author | Van de Werf, Frans | - |
dc.contributor.author | Anderson, Jeffrey L. | - |
dc.contributor.author | White, Harvey D. | - |
dc.contributor.author | Verheugt, Freek W. A. | - |
dc.contributor.author | Pedersen, Terje R. | - |
dc.contributor.author | DeMets, David L. | - |
dc.contributor.author | Lowe, Cheryl | - |
dc.contributor.author | Arevalo, Christina | - |
dc.contributor.author | Awtry, Eric | - |
dc.contributor.author | Berger, Clifford | - |
dc.contributor.author | Croce, Kevin | - |
dc.contributor.author | Desai, Akshay | - |
dc.contributor.author | Gelfand, Eli | - |
dc.contributor.author | Ho, Carolyn | - |
dc.contributor.author | Leeman, David | - |
dc.contributor.author | Link, Mark | - |
dc.contributor.author | Norden, Andrew | - |
dc.contributor.author | Pande, Ashvin | - |
dc.contributor.author | Rost, Natalia | - |
dc.contributor.author | Ruberg, Frederick | - |
dc.contributor.author | Silverman, Scott | - |
dc.contributor.author | Singhal, Aneesh | - |
dc.contributor.author | Vita, Joseph | - |
dc.contributor.author | Alvarisqueta, A. | - |
dc.contributor.author | De Gennaro, N. | - |
dc.contributor.author | Berli, M. | - |
dc.contributor.author | Roude, A. E. | - |
dc.contributor.author | Di Gennaro, J. Albisu | - |
dc.contributor.author | Albisu, J. F. | - |
dc.contributor.author | Caccavo, A. | - |
dc.contributor.author | Torres, M. | - |
dc.contributor.author | Cuadrado, J. | - |
dc.contributor.author | Bordoni, P. | - |
dc.contributor.author | Cuello, J. | - |
dc.contributor.author | Aviles, A. | - |
dc.contributor.author | Glenny, A. | - |
dc.contributor.author | Recoaro, R. | - |
dc.contributor.author | Fernandez, R. | - |
dc.contributor.author | Strada, B. N. | - |
dc.contributor.author | Fuentealba, V. | - |
dc.contributor.author | Gallo, C. | - |
dc.contributor.author | Duran, R. Garc-a | - |
dc.contributor.author | Garcia, C. | - |
dc.contributor.author | Hominal, M. | - |
dc.contributor.author | Castoldi, M. | - |
dc.contributor.author | Jure, H. | - |
dc.contributor.author | Pacora, F. Ferre | - |
dc.contributor.author | Lorenzatti, A. | - |
dc.contributor.author | Martinez, J. M. | - |
dc.contributor.author | Macin, S. | - |
dc.contributor.author | Cocco, N. | - |
dc.contributor.author | MacKinnon, I. | - |
dc.contributor.author | Bagnato, M. B. | - |
dc.contributor.author | Marino, J. | - |
dc.contributor.author | Cusimano, S. | - |
dc.contributor.author | Arias, V. | - |
dc.contributor.author | Focaccia, M. | - |
dc.contributor.author | Muntaner, J. | - |
dc.contributor.author | Mansilla, V. | - |
dc.contributor.author | Poy, C. | - |
dc.contributor.author | Prado, A. | - |
dc.contributor.author | Paterlini, G. | - |
dc.contributor.author | Montana, O. | - |
dc.contributor.author | Camino, A. | - |
dc.contributor.author | Sala, J. | - |
dc.contributor.author | Luciani, C. | - |
dc.contributor.author | Vico, M. | - |
dc.contributor.author | Morell, Y. | - |
dc.contributor.author | Dumont, C. | - |
dc.contributor.author | Vottero, E. | - |
dc.contributor.author | Zangroniz, P. | - |
dc.contributor.author | Lescano, A. | - |
dc.contributor.author | Morara, P. | - |
dc.contributor.author | Marquez, L. Lobo | - |
dc.contributor.author | Patron, F. Risso | - |
dc.contributor.author | Labarta, G. Bustamante | - |
dc.contributor.author | Sivila, C. D. | - |
dc.contributor.author | Quiroga, A. R. | - |
dc.contributor.author | Maffei, L. | - |
dc.contributor.author | Sassone, S. | - |
dc.contributor.author | Rolandi, F. | - |
dc.contributor.author | Vesentini, N. | - |
dc.contributor.author | Carnero, G. | - |
dc.contributor.author | Del Verme, S. | - |
dc.contributor.author | Hershson, A. | - |
dc.contributor.author | Figal, J. C. | - |
dc.contributor.author | Viso, M. E. | - |
dc.contributor.author | Hii, C. | - |
dc.contributor.author | Smith, K. | - |
dc.contributor.author | Singh, B. | - |
dc.contributor.author | Acampo, M. | - |
dc.contributor.author | Rogers, J. | - |
dc.contributor.author | ODonoghue, M. | - |
dc.contributor.author | Amerena, J. | - |
dc.contributor.author | Long, A. | - |
dc.contributor.author | Dart, A. | - |
dc.contributor.author | Kay, S. | - |
dc.contributor.author | Worthley, M. | - |
dc.contributor.author | Nimmo, J. | - |
dc.contributor.author | Lehman, R. | - |
dc.contributor.author | Morrison, H. | - |
dc.contributor.author | Dick, R. | - |
dc.contributor.author | Savage, C. | - |
dc.contributor.author | van Gaal, W. | - |
dc.contributor.author | Park, M. | - |
dc.contributor.author | Blombery, P. | - |
dc.contributor.author | McCarthy, C. | - |
dc.contributor.author | Oqueli, E. | - |
dc.contributor.author | Hill, D. | - |
dc.contributor.author | Sader, M. | - |
dc.contributor.author | Vrachas, D. | - |
dc.contributor.author | Purnell, P. | - |
dc.contributor.author | Vibert, J. | - |
dc.contributor.author | Collins, N. | - |
dc.contributor.author | Gordon, A. | - |
dc.contributor.author | Arstall, M. | - |
dc.contributor.author | Rose, J. | - |
dc.contributor.author | Aroney, C. | - |
dc.contributor.author | Cleave, P. | - |
dc.contributor.author | Fitzpatrick, M. | - |
dc.contributor.author | Mackenzie, M. | - |
dc.contributor.author | Garrahy, P. | - |
dc.contributor.author | Hall, C. | - |
dc.contributor.author | Nelson, G. | - |
dc.contributor.author | Reid, E. | - |
dc.contributor.author | Lee, A. | - |
dc.contributor.author | Gibbs, J. | - |
dc.contributor.author | Thompson, P. | - |
dc.contributor.author | Crittenden, J. | - |
dc.contributor.author | Hammett, C. | - |
dc.contributor.author | Hindom, L. | - |
dc.contributor.author | Antonis, P. | - |
dc.contributor.author | Manzoney, A. | - |
dc.contributor.author | Cross, D. | - |
dc.contributor.author | Pollard, C. | - |
dc.contributor.author | Brieger, D. | - |
dc.contributor.author | Wu, J. | - |
dc.contributor.author | Whelan, A. | - |
dc.contributor.author | Tulloch, G. | - |
dc.contributor.author | Taylor, A. | - |
dc.contributor.author | Smith, B. | - |
dc.contributor.author | Horowitz, J. | - |
dc.contributor.author | Black, M. | - |
dc.contributor.author | Boland, J. | - |
dc.contributor.author | Malmendier, D. | - |
dc.contributor.author | Celen, H. | - |
dc.contributor.author | Wendelen, E. | - |
dc.contributor.author | Claeys, M. | - |
dc.contributor.author | Pieter, M. | - |
dc.contributor.author | Cools, F. | - |
dc.contributor.author | Simons, N. | - |
dc.contributor.author | De Maeseneire, S. | - |
dc.contributor.author | De Wolf, L. | - |
dc.contributor.author | Brike, C. | - |
dc.contributor.author | Dubois, P. | - |
dc.contributor.author | Bolado, A. Conde Y. | - |
dc.contributor.author | Foading-Deffo, B. | - |
dc.contributor.author | Tahon, S. | - |
dc.contributor.author | Friart, A. | - |
dc.contributor.author | Arend, C. | - |
dc.contributor.author | Gevaert, S. | - |
dc.contributor.author | Verdegem, P. | - |
dc.contributor.author | Marechal, P. | - |
dc.contributor.author | Gits, F. | - |
dc.contributor.author | Pierard, L. | - |
dc.contributor.author | Celentano, C. | - |
dc.contributor.author | Pirenne, B. | - |
dc.contributor.author | Bouvy, C. | - |
dc.contributor.author | Renkin, J. | - |
dc.contributor.author | Huyberechts, D. | - |
dc.contributor.author | Sinnaeve, P. | - |
dc.contributor.author | De Velder, L. | - |
dc.contributor.author | Stammen, F. | - |
dc.contributor.author | Casier, T. | - |
dc.contributor.author | Striekwold, H. | - |
dc.contributor.author | Van den Broeck, D. | - |
dc.contributor.author | Thoeng, J. | - |
dc.contributor.author | Goris, R. | - |
dc.contributor.author | Timmermans, P. | - |
dc.contributor.author | Collard, S. -J. | - |
dc.contributor.author | van de Borne, P. | - |
dc.contributor.author | De Clippel, M. | - |
dc.contributor.author | Wollaert, B. | - |
dc.contributor.author | Jacobs, C. | - |
dc.contributor.author | Vankelecom, B. | - |
dc.contributor.author | Daelemans, Y. | - |
dc.contributor.author | Vervoort, G. | - |
dc.contributor.author | Drieghe, S. | - |
dc.contributor.author | Vranckx, P. | - |
dc.contributor.author | Janssen, A. | - |
dc.contributor.author | Vrolix, M. | - |
dc.contributor.author | I., Simenon | - |
dc.contributor.author | Wijns, W. | - |
dc.contributor.author | Delacroix, H. | - |
dc.contributor.author | Denie, D. | - |
dc.contributor.author | Schoors, D. | - |
dc.contributor.author | Lemoine, I. | - |
dc.contributor.author | Cornelis, K. | - |
dc.contributor.author | Willems, A. -M. | - |
dc.contributor.author | Schroder, E. | - |
dc.contributor.author | Domange, J. | - |
dc.contributor.author | Greque, G. | - |
dc.contributor.author | Machado, H. | - |
dc.contributor.author | Armaganijan, D. | - |
dc.contributor.author | Del Monaco, M. I. | - |
dc.contributor.author | da Silva, D. | - |
dc.contributor.author | Nakazone, R. | - |
dc.contributor.author | Dutra, O. | - |
dc.contributor.author | R., Vaz | - |
dc.contributor.author | Daher, R. | - |
dc.contributor.author | Rodrigues, D. | - |
dc.contributor.author | Guimaraes, A. | - |
dc.contributor.author | Teixeira, A. | - |
dc.contributor.author | Saraiva, J. | - |
dc.contributor.author | Costa, M. | - |
dc.contributor.author | Leaes, P. | - |
dc.contributor.author | Blacher, M. | - |
dc.contributor.author | Maia, L. | - |
dc.contributor.author | Nakazone, MA. | - |
dc.contributor.author | Manenti, E. | - |
dc.contributor.author | Ruschel, K. | - |
dc.contributor.author | Marin-Neto, J. | - |
dc.contributor.author | Pavao, R. | - |
dc.contributor.author | Preto, Riberao | - |
dc.contributor.author | Junior, A. Alves | - |
dc.contributor.author | Oliveira, G. | - |
dc.contributor.author | Rassi, S. | - |
dc.contributor.author | Sampaio, D. | - |
dc.contributor.author | Rossi, P. R. | - |
dc.contributor.author | dos Santos, L. | - |
dc.contributor.author | de Souza, J. | - |
dc.contributor.author | Lino, E. | - |
dc.contributor.author | Pimentel Filho, P. | - |
dc.contributor.author | Zucchetti, C. | - |
dc.contributor.author | Gomes, M. | - |
dc.contributor.author | de Paiva, A. | - |
dc.contributor.author | Sousa, A. C. | - |
dc.contributor.author | Almeida, A. | - |
dc.contributor.author | Botelho, R. | - |
dc.contributor.author | da Silva, R. | - |
dc.contributor.author | Giraldez, R. | - |
dc.contributor.author | Franken, M. | - |
dc.contributor.author | Faludi, A. | - |
dc.contributor.author | Bertolami, M. | - |
dc.contributor.author | Hernandes, M. | - |
dc.contributor.author | Lucas, N. | - |
dc.contributor.author | Carvalho, A. | - |
dc.contributor.author | Bertolami, A. | - |
dc.contributor.author | Precoma, D. | - |
dc.contributor.author | Geralde, L. | - |
dc.contributor.author | Pereira, A. | - |
dc.contributor.author | Cesar, L. | - |
dc.contributor.author | Mioto, B. | - |
dc.contributor.author | Marino, R. | - |
dc.contributor.author | Rabelo, W. | - |
dc.contributor.author | dos Santos, F. | - |
dc.contributor.author | Vidotti, M. H. | - |
dc.contributor.author | Mangione, J. | - |
dc.contributor.author | Mauro, M. | - |
dc.contributor.author | Kormann, A. | - |
dc.contributor.author | Ultramari, F. | - |
dc.contributor.author | Zimmermann, S. | - |
dc.contributor.author | Michalaros, Y. | - |
dc.contributor.author | Fonseca, M. | - |
dc.contributor.author | Sampaio, C. | - |
dc.contributor.author | Eliaschewitz, F. | - |
dc.contributor.author | Barbosa, E. | - |
dc.contributor.author | Drews, C. | - |
dc.contributor.author | de Lorenzo, A. | - |
dc.contributor.author | Barros, C. | - |
dc.contributor.author | Cancado, G. | - |
dc.contributor.author | Neuesnchwander, F. | - |
dc.contributor.author | Zimmermann, E. | - |
dc.contributor.author | Chompalova, B. | - |
dc.contributor.author | Denchev, S. | - |
dc.contributor.author | Gocheva, N. | - |
dc.contributor.author | Mihov, A. | - |
dc.contributor.author | Mincheva, V. | - |
dc.contributor.author | Pencheva, G. | - |
dc.contributor.author | Gelev, V. | - |
dc.contributor.author | Tisheva, S. | - |
dc.contributor.author | Todorov, G. | - |
dc.contributor.author | Goudev, A. | - |
dc.contributor.author | Parvanova, Z. | - |
dc.contributor.author | Peneva, Y. | - |
dc.contributor.author | Todorova, M. | - |
dc.contributor.author | Mitkova, M. | - |
dc.contributor.author | Smilov, L. | - |
dc.contributor.author | Yakovova, S. | - |
dc.contributor.author | Milanova, K. | - |
dc.contributor.author | Aleksov, N. | - |
dc.contributor.author | Mollov, M. | - |
dc.contributor.author | Gergova, V. | - |
dc.contributor.author | Shishmanova, D. | - |
dc.contributor.author | Stoykov, A. | - |
dc.contributor.author | Hristova, K. | - |
dc.contributor.author | Uzunangelov, Y. | - |
dc.contributor.author | Postadzhian, A. | - |
dc.contributor.author | Peltegov, V. | - |
dc.contributor.author | Karamitev, G. | - |
dc.contributor.author | Benov, H. | - |
dc.contributor.author | Vasileva, D. | - |
dc.contributor.author | Parishev, G. | - |
dc.contributor.author | Milcheva, N. | - |
dc.contributor.author | Avramov, D. | - |
dc.contributor.author | Miteva, B. | - |
dc.contributor.author | Stoyanovski, V. | - |
dc.contributor.author | Pencheva, G. | - |
dc.contributor.author | Nikolova, L. | - |
dc.contributor.author | Stancheva, N. | - |
dc.contributor.author | Nyagina, M. | - |
dc.contributor.author | Markov, D. | - |
dc.contributor.author | Spirova, D. | - |
dc.contributor.author | Peneva, Y. | - |
dc.contributor.author | Peshkov, O. | - |
dc.contributor.author | Mitkova, L. | - |
dc.contributor.author | Mandzhukova, S. | - |
dc.contributor.author | Rangelova, V. | - |
dc.contributor.author | Ivanov, K. | - |
dc.contributor.author | Krusheva, B. | - |
dc.contributor.author | Raycheva, V. | - |
dc.contributor.author | Gergova, V. | - |
dc.contributor.author | Goranov, K. | - |
dc.contributor.author | Stoykov, A. | - |
dc.contributor.author | Staleva, M. | - |
dc.contributor.author | Rashkova, V. | - |
dc.contributor.author | Postadzhian, A. | - |
dc.contributor.author | Krancheva, V. | - |
dc.contributor.author | Lulova, E. | - |
dc.contributor.author | Delchev, Gotse | - |
dc.contributor.author | Cantor, W. | - |
dc.contributor.author | Constance, C. | - |
dc.contributor.author | Gosselin, G. | - |
dc.contributor.author | Gosselin, G. | - |
dc.contributor.author | Marr, D. | - |
dc.contributor.author | Pandey, A. S. | - |
dc.contributor.author | Pesant, Y. | - |
dc.contributor.author | Pouliot, J. | - |
dc.contributor.author | Gladstone, P. | - |
dc.contributor.author | McPherson, T. | - |
dc.contributor.author | Rupka, D. | - |
dc.contributor.author | Saw, J. | - |
dc.contributor.author | St-Amour, E. | - |
dc.contributor.author | Syan, G. | - |
dc.contributor.author | Syan, R. | - |
dc.contributor.author | Rosenbloom, A. | - |
dc.contributor.author | Vizel, S. | - |
dc.contributor.author | Della Siega, A. | - |
dc.contributor.author | Halperin, F. | - |
dc.contributor.author | Nigro, F. | - |
dc.contributor.author | Chehayeb, R. | - |
dc.contributor.author | Fell, D. | - |
dc.contributor.author | Labonte, R. | - |
dc.contributor.author | Nawaz, S. | - |
dc.contributor.author | Gupta, M. | - |
dc.contributor.author | Ma, P. | - |
dc.contributor.author | Glanz, A. | - |
dc.contributor.author | Kouz, S. | - |
dc.contributor.author | Bhargava, R. | - |
dc.contributor.author | Dion, D. | - |
dc.contributor.author | Dupuis, R. | - |
dc.contributor.author | Grondin, F. | - |
dc.contributor.author | Wong, B. | - |
dc.contributor.author | Sabbah, E. | - |
dc.contributor.author | Hui, W. | - |
dc.contributor.author | Belisle, P. | - |
dc.contributor.author | Tymchak, W. | - |
dc.contributor.author | Montigny, M. | - |
dc.contributor.author | Lonn, E. | - |
dc.contributor.author | Bose, S. | - |
dc.contributor.author | Kincade, D. | - |
dc.contributor.author | Gallo, R. | - |
dc.contributor.author | Lamy, A. | - |
dc.contributor.author | Bell, A. | - |
dc.contributor.author | LeMay, M. | - |
dc.contributor.author | Bata, I. | - |
dc.contributor.author | Kostuk, W. | - |
dc.contributor.author | Cheung, S. | - |
dc.contributor.author | Petrella, R. | - |
dc.contributor.author | Lubelsky, B. | - |
dc.contributor.author | Berlingieri, J. | - |
dc.contributor.author | Fortin, C. | - |
dc.contributor.author | DeYoung, J. P. | - |
dc.contributor.author | Babapulle, M. | - |
dc.contributor.author | Landry, D. | - |
dc.contributor.author | Gupta, A. | - |
dc.contributor.author | Bertrand, O. | - |
dc.contributor.author | Jadin, M. | - |
dc.contributor.author | Robbins, K. | - |
dc.contributor.author | Gauthier, M. -F. | - |
dc.contributor.author | Masson, C. | - |
dc.contributor.author | Reyes, V. | - |
dc.contributor.author | O'Blenis, G. | - |
dc.contributor.author | Clarus, S. | - |
dc.contributor.author | Sardin, V. | - |
dc.contributor.author | Marquette, S. | - |
dc.contributor.author | Bozek, B. | - |
dc.contributor.author | Spurrell, D. | - |
dc.contributor.author | Thiessen, S. | - |
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dc.contributor.author | Meholick, A. | - |
dc.contributor.author | Hejna, E. | - |
dc.contributor.author | Anderson, R. D. | - |
dc.contributor.author | Long, S. | - |
dc.contributor.author | Parikh, S. | - |
dc.contributor.author | Norton, N. | - |
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dc.contributor.author | Stepanov, N. | - |
dc.date.accessioned | 2021-09-14T10:20:14Z | - |
dc.date.available | 2021-09-14T10:20:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05-07 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/126754 | - |
dc.description.abstract | BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MASSACHUSETTS MEDICAL SOC | - |
dc.subject | ASSOCIATION TASK-FORCE | - |
dc.subject | ACUTE CORONARY SYNDROMES | - |
dc.subject | AMERICAN-COLLEGE | - |
dc.subject | ESC GUIDELINES | - |
dc.subject | CLOPIDOGREL | - |
dc.subject | MANAGEMENT | - |
dc.subject | ASPIRIN | - |
dc.subject | PREVENTION | - |
dc.subject | PRASUGREL | - |
dc.subject | ANGIOGRAPHY | - |
dc.title | Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, D. -S. | - |
dc.identifier.doi | 10.1056/NEJMoa1500857 | - |
dc.identifier.wosid | 000353974700004 | - |
dc.identifier.bibliographicCitation | NEW ENGLAND JOURNAL OF MEDICINE, v.372, no.19, pp.1791 - 1800 | - |
dc.relation.isPartOf | NEW ENGLAND JOURNAL OF MEDICINE | - |
dc.citation.title | NEW ENGLAND JOURNAL OF MEDICINE | - |
dc.citation.volume | 372 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1791 | - |
dc.citation.endPage | 1800 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ASSOCIATION TASK-FORCE | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROMES | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | ESC GUIDELINES | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PRASUGREL | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
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