Pathological predictive factors for late recurrence of hepatocellular carcinoma in chronic liver disease
DC Field | Value | Language |
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dc.contributor.author | Nahm, Ji H. | - |
dc.contributor.author | Lee, Hye S. | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.contributor.author | Yim, Sun Y. | - |
dc.contributor.author | Shin, Ji-hyun | - |
dc.contributor.author | Yoo, Jeong E. | - |
dc.contributor.author | Ahn, Sang H. | - |
dc.contributor.author | Choi, Jin S. | - |
dc.contributor.author | Lee, Ju-Seog | - |
dc.contributor.author | Park, Young N. | - |
dc.date.accessioned | 2021-11-17T13:40:58Z | - |
dc.date.available | 2021-11-17T13:40:58Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/127761 | - |
dc.description.abstract | Background & Aims Late recurrence of hepatocellular carcinoma (HCC) is regarded as de novo HCC from chronic hepatitis. This study investigated clinicopathological and molecular factors to develop a nomogram for predicting late HCC recurrence (>2 years after curative resection). Methods The training and validation cohorts included HCC patients with a major aetiology of hepatitis B who underwent curative resection. Clinicopathological features including lobular and porto-periportal inflammatory activity, fibrosis and liver cell change were evaluated. Proteins encoded by genes related to late recurrence were identified using a reverse phase protein array of 95 non-tumourous liver tissues. Immunoexpression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), plasminogen activator inhibitor-1, phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) and spleen tyrosine kinase (SYK) was measured. Results Late recurrence occurred in 74/402 (18%) and 47/243 (19%) in the training and validation cohorts respectively. Cirrhosis, moderate/severe lobular inflammatory activity, and expression of pSTAT3, pERK1/2, and SYK proteins correlated to the gene signature of hepatocyte injury and regeneration were independently associated with late recurrence, with odds ratios (95% confidence intervals) of 2.0 (1.2-3.3), 21.1 (4.3-102.7) and 6.0 (2.1-17.7) respectively (P .05 for all). A nomogram based on these variables (histological parameters and immunohistochemical marker combinations) showed high reliability in both the training and validation cohorts (Harrell's C index: 0.701 and 0.716; 95% confidence intervals: 0.64-0.76 and 0.64-0.79 respectively). Conclusions The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis (fibrosis) predicts late HCC recurrence. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Pathological predictive factors for late recurrence of hepatocellular carcinoma in chronic liver disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yim, Sun Y. | - |
dc.identifier.doi | 10.1111/liv.14835 | - |
dc.identifier.scopusid | 2-s2.0-85103171073 | - |
dc.identifier.wosid | 000632577500001 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, v.41, no.7, pp.1662 - 1674 | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.citation.title | LIVER INTERNATIONAL | - |
dc.citation.volume | 41 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1662 | - |
dc.citation.endPage | 1674 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | LATE INTRAHEPATIC RECURRENCE | - |
dc.subject.keywordPlus | CELL DYSPLASIA | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | SERINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | STAT3 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.subject.keywordAuthor | chronic hepatitis | - |
dc.subject.keywordAuthor | cirrhosis | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | nomogram | - |
dc.subject.keywordAuthor | recurrence | - |
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