SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells
DC Field | Value | Language |
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dc.contributor.author | Jung, Jae Hyung | - |
dc.contributor.author | Rha, Min-Seok | - |
dc.contributor.author | Sa, Moa | - |
dc.contributor.author | Choi, Hee Kyoung | - |
dc.contributor.author | Jeon, Ji Hoon | - |
dc.contributor.author | Seok, Hyeri | - |
dc.contributor.author | Park, Dae Won | - |
dc.contributor.author | Park, Su-Hyung | - |
dc.contributor.author | Jeong, Hye Won | - |
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.date.accessioned | 2021-11-18T00:40:32Z | - |
dc.date.available | 2021-11-18T00:40:32Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-06-30 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/127813 | - |
dc.description.abstract | Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex vivo assays to evaluate SARS-CoV-2-specific CD4(+) and CD8(+) T cell responses in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO), and find that memory T cell responses are maintained during the study period regardless of the severity of COVID-19. In particular, we observe sustained polyfunctionality and proliferation capacity of SARS-CoV-2-specific T cells. Among SARS-CoV-2-specific CD4(+) and CD8(+) T cells detected by activation-induced markers, the proportion of stem cell-like memory T (T-SCM) cells is increased, peaking at approximately 120 DPSO. Development of T-SCM cells is confirmed by SARS-CoV-2-specific MHC-I multimer staining. Considering the self-renewal capacity and multipotency of T-SCM cells, our data suggest that SARS-CoV-2-specific T cells are long-lasting after recovery from COVID-19, thus support the feasibility of effective vaccination programs as a measure for COVID-19 control. T cells are instrumental to protective immune responses against SARS-CoV-2, the pathogen responsible for the COVID-19 pandemic. Here the authors show that, in convalescent COVID-19 patients, memory T cell responses are detectable up to 317 days post-symptom onset, in which the presence of stem cell-like memory T cells further hints long-lasting immunity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.subject | RESPONSES | - |
dc.title | SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Won Suk | - |
dc.identifier.doi | 10.1038/s41467-021-24377-1 | - |
dc.identifier.scopusid | 2-s2.0-85109137953 | - |
dc.identifier.wosid | 000671795500003 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RESPONSES | - |
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