Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy
DC Field | Value | Language |
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dc.contributor.author | Roh, Yoon Ho | - |
dc.contributor.author | Eom, Ji Yeon | - |
dc.contributor.author | Choi, Dae Gun | - |
dc.contributor.author | Moon, Ju Yeon | - |
dc.contributor.author | Shim, Min Suk | - |
dc.contributor.author | Bong, Ki Wan | - |
dc.date.accessioned | 2021-11-18T01:41:04Z | - |
dc.date.available | 2021-11-18T01:41:04Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-06-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/127821 | - |
dc.description.abstract | Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) micro particles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOXGNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light triggered drug release. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | MICROFLUIDIC FABRICATION | - |
dc.subject | HYDROGEL MICROPARTICLES | - |
dc.subject | PHOTOTHERMAL THERAPY | - |
dc.subject | PHASE-TRANSITION | - |
dc.subject | RELEASE | - |
dc.subject | DELIVERY | - |
dc.subject | POLY(N-VINYLCAPROLACTAM) | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | EFFICIENCY | - |
dc.title | Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bong, Ki Wan | - |
dc.identifier.doi | 10.1016/j.jiec.2021.03.052 | - |
dc.identifier.scopusid | 2-s2.0-85104460443 | - |
dc.identifier.wosid | 000644367400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.98, pp.211 - 216 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 98 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 216 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002734478 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | EFFICIENCY | - |
dc.subject.keywordPlus | HYDROGEL MICROPARTICLES | - |
dc.subject.keywordPlus | MICROFLUIDIC FABRICATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PHASE-TRANSITION | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | POLY(N-VINYLCAPROLACTAM) | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | Cancer therapy | - |
dc.subject.keywordAuthor | Gold nanorod | - |
dc.subject.keywordAuthor | NIR light | - |
dc.subject.keywordAuthor | Photothermal effect | - |
dc.subject.keywordAuthor | Poly(N-vinyl caprolactam) | - |
dc.subject.keywordAuthor | Stop-flow lithography | - |
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