Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis
- Authors
- Batara, Don Carlo Ramos; Choi, Moon-Chang; Shin, Hyeon-Uk; Kim, Hyunggee; Kim, Sung-Hak
- Issue Date
- 6월-2021
- Publisher
- MDPI
- Keywords
- glioblastoma multiforme; autophagy; treatment
- Citation
- CELLS, v.10, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLS
- Volume
- 10
- Number
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/127952
- DOI
- 10.3390/cells10061411
- ISSN
- 2073-4409
- Abstract
- Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy's pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.