Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Song, Juhyun | - |
dc.contributor.author | Park, Dae Won | - |
dc.contributor.author | Cha, Jae-hyung | - |
dc.contributor.author | Seok, Hyeri | - |
dc.contributor.author | Kim, Joo Yeong | - |
dc.contributor.author | Park, Jonghak | - |
dc.contributor.author | Cho, Hanjin | - |
dc.date.accessioned | 2021-11-19T20:40:42Z | - |
dc.date.available | 2021-11-19T20:40:42Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-05-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128035 | - |
dc.description.abstract | We investigated association between epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients and clinical outcomes in Korea. This nationwide retrospective cohort study included 5621 discharged patients with COVID-19, extracted from the Korea Disease Control and Prevention Agency (KDCA) database. We compared clinical data between survivors (n=5387) and non-survivors (n=234). We used logistic regression analysis and Cox proportional hazards model to explore risk factors of death and fatal adverse outcomes. Increased odds ratio (OR) of mortality occurred with age (>= 60 years) [OR 11.685, 95% confidence interval (CI) 4.655-34.150, p<0.001], isolation period, dyspnoea, altered mentality, diabetes, malignancy, dementia, and intensive care unit (ICU) admission. The multivariable regression equation including all potential variables predicted mortality (AUC=0.979, 95% CI 0.964-0.993). Cox proportional hazards model showed increasing hazard ratio (HR) of mortality with dementia (HR 6.376, 95% CI 3.736-10.802, p<0.001), ICU admission (HR 4.233, 95% CI 2.661-6.734, p<0.001), age >= 60 years (HR 3.530, 95% CI 1.664-7.485, p=0.001), malignancy (HR 3.054, 95% CI 1.494-6.245, p=0.002), and dyspnoea (HR 1.823, 95% CI 1.125-2.954, p=0.015). Presence of dementia, ICU admission, age >= 60 years, malignancy, and dyspnoea could help clinicians identify COVID-19 patients with poor prognosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.subject | MORTALITY | - |
dc.subject | PNEUMONIA | - |
dc.subject | WUHAN | - |
dc.subject | CHINA | - |
dc.title | Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Juhyun | - |
dc.contributor.affiliatedAuthor | Cho, Hanjin | - |
dc.identifier.doi | 10.1038/s41598-021-89548-y | - |
dc.identifier.scopusid | 2-s2.0-85105803909 | - |
dc.identifier.wosid | 000652602100016 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | WUHAN | - |
dc.subject.keywordPlus | CHINA | - |
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