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Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions

Authors
Park, Eun-JungKang, Min-SungLim, Hyun-JiKang, Tae KyuJin, Seung-WooLee, Seung HyeunBaek, Sun HwaKang, Jeong Won
Issue Date
1-5월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Disinfectants; Lamellar bodies; The nuclear matrix cleavage; Mitochondria; Interstitial fibrosis
Citation
TOXICOLOGY AND APPLIED PHARMACOLOGY, v.418
Indexed
SCIE
SCOPUS
Journal Title
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume
418
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128061
DOI
10.1016/j.taap.2021.115501
ISSN
0041-008X
Abstract
With the rapid increase in application of disinfectants worldwide as a method to block the spread of coronavirus, many new products are being introduced into the market without thorough verification of their impacts on human health and the environment. In the present study, we aimed to propose a screening marker for materials that can induce fibrotic lung disease using disinfectants, which had been demonstrated as causative materials of chronic inflammation and interstitial fibrosis. We first calculated the corresponding LC50 level based on results from cell viability test and exposed the LC50 level of disinfectants to human bronchial epithelial cells for 24 h. Formation of lamellar body-like structures, cleavage of the nuclear matrix, structural damage of mitochondria were found in the cytosol of the treated cells. We also dosed disinfectants by pharyngeal aspiration to mice to determine the LD0 level. The mice were sacrificed on Day 14 after a single dosing, and lamellar body-like structures were observed in the lung tissue of mice. Herein, we hypothesize that DNA damage and metabolic disturbance may play central roles in disinfectant-induced adverse health effects. Additionally, we propose that formation of lamellar bodies can be a screening marker for interstitial fibrosis.
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Graduate School of Energy and Environment (KU-KIST GREEN SCHOOL) > Department of Energy and Environment > 1. Journal Articles

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Kang, Jeong Won
공과대학 (화공생명공학과)
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