Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | You, Jaehwan | - |
dc.contributor.author | Seok, Jong Hyeon | - |
dc.contributor.author | Joo, Myungsoo | - |
dc.contributor.author | Bae, Joon-Yong | - |
dc.contributor.author | Kim, Jin Il | - |
dc.contributor.author | Park, Man-Seong | - |
dc.contributor.author | Kim, Kisoon | - |
dc.date.accessioned | 2021-11-20T03:40:31Z | - |
dc.date.available | 2021-11-20T03:40:31Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128069 | - |
dc.description.abstract | The most effective way to control newly emerging infectious disease, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, is to strengthen preventative or therapeutic public health strategies before the infection spreads worldwide. However, global health systems remain at the early stages in anticipating effective therapeutics or vaccines to combat the SARS-CoV-2 pandemic. While maintaining social distance is the most crucial metric to avoid spreading the virus, symptomatic therapy given to patients on the clinical manifestations helps save lives. The molecular properties of SARS-CoV-2 infection have been quickly elucidated, paving the way to therapeutics, vaccine development, and other medical interventions. Despite this progress, the detailed biomolecular mechanism of SARS-CoV-2 infection remains elusive. Given virus invasion of cells is a determining factor for virulence, understanding the viral entry process can be a mainstay in controlling newly emerged viruses. Since viral entry is mediated by selective cellular proteases or proteins associated with receptors, identification and functional analysis of these proteins could provide a way to disrupt virus propagation. This review comprehensively discusses cellular machinery necessary for SARS-CoV-2 infection. Understanding multifactorial traits of the virus entry will provide a substantial guide to facilitate antiviral drug development. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.title | Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jin Il | - |
dc.contributor.affiliatedAuthor | Park, Man-Seong | - |
dc.contributor.affiliatedAuthor | Kim, Kisoon | - |
dc.identifier.doi | 10.4062/biomolther.2021.048 | - |
dc.identifier.scopusid | 2-s2.0-85105675834 | - |
dc.identifier.wosid | 000652473600001 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.29, no.2, pp.249 - 262 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 262 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002708634 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RESPIRATORY-SYNDROME-CORONAVIRUS | - |
dc.subject.keywordPlus | CONVERTING ENZYME 2 | - |
dc.subject.keywordPlus | PATHOGENIC AVIAN INFLUENZA | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | SPIKE PROTEIN | - |
dc.subject.keywordPlus | SARS-COV | - |
dc.subject.keywordPlus | CLEAVAGE-SITE | - |
dc.subject.keywordPlus | VIRUS ENTRY | - |
dc.subject.keywordPlus | PROPROTEIN CONVERTASES | - |
dc.subject.keywordPlus | FUNCTIONAL RECEPTOR | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | Cell entry | - |
dc.subject.keywordAuthor | Cellular proteins | - |
dc.subject.keywordAuthor | Antiviral drugs | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.