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The Relationship between Plasma Erythropoietin Levels and Symptoms of Attention Deficit Hyperactivity Disorder

Authors
Shim, Se-HoonKim, Yong-KuHwangbo, YoungYoon, Hee-JungKim, Ji SunLee, Youn JungWoo, Young SupBahk, Won-Myong
Issue Date
5월-2021
Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
Keywords
Attention deficit hyperactivity disorder; Erythropoietin; Neuroprotection; Neurodevelopment
Citation
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.19, no.2, pp.334 - 340
Indexed
SCIE
SCOPUS
KCI
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume
19
Number
2
Start Page
334
End Page
340
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128110
DOI
10.9758/cpn.2021.19.2.334
ISSN
1738-1088
Abstract
Objective: There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this study was to examine the EPO plasma levels and determine whether there was any correlation between plasma EPO levels and clinical characteristics of ADHD. Methods: Plasma EPO levels were measured in 78 drug-naive children with ADHD and in 81 healthy children. The severity of ADHD symptoms was determined by scores on the Korean ADHD Rating Scale (K-ARS) in ADHD children and healthy controls. Results: The difference between median plasma EPO levels in ADHD children and in healthy controls was not statistically significant. Adjusting for age and sex, a linear regression analysis showed that inattention score was significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Hyperactivity-impulsivity score was significantly higher in the highest tertile of plasma EPO compared to those in the lowest tertile. Moreover, total K-ARS scores were significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Conclusion: These findings suggest that plasma EPO levels were related to some ADHD symptoms, which could be used in the monitoring of the disorder.
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