SP-8356, a (15)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-kappa B and ERK Signaling
- Authors
- Kim, Dong Hwi; Yong, Hyo Jeong; Mander, Sunam; Huong Thi Nguyen; Lan Phuong Nguyen; Park, Hee-Kyung; Cha, Hyo Kyeong; Kim, Won-Ki; Hwang, Jong-Ik
- Issue Date
- 5월-2021
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- SP-8356; Liver cancer; Proliferation; Motility; ERK; NF-kappa B
- Citation
- BIOMOLECULES & THERAPEUTICS, v.29, no.2, pp.331 - 341
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 29
- Number
- 2
- Start Page
- 331
- End Page
- 341
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128123
- DOI
- 10.4062/biomolther.2020.200
- ISSN
- 1976-9148
- Abstract
- Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer arises in the context of hepatic inflammation, such as hepatitis B virus and hepatitis C virus infection. Despite significant improvements in the therapeutic modalities for liver cancer, patient prognosis is not satisfactory due to the limited efficacy of current drug therapies in anti-metastatic activity. Therefore, developing new effective anti-cancer agents with anti-metastatic activity is important for the treatment of liver cancer. In this study, SP-8356, a verbenone derivative with anti-inflammatory activity, was investigated for its effect on the growth and migration of liver cancer cells. Our findings demonstrated that SP-8356 inhibits the proliferation of liver cancer cells by inducing apoptosis and suppressing the mobility and invasion ability of liver cancer cells. Functional studies revealed that SP-8356 inhibits the mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways, which are related to cell proliferation and metastasis, resulting in the downregulation of metastasis-related genes. Moreover, using an orthotopic liver cancer model, tumor growth was significantly decreased following treatment with SP-8356. Thus, this study suggests that SP-8356 may be a potential agent for the treatment of liver cancer with multimodal regulation.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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