Amyloid Positivity in the Alzheimer/Subcortical-Vascular Spectrum
DC Field | Value | Language |
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dc.contributor.author | Kang, Sung Hoon | - |
dc.contributor.author | Kim, Monica Eunseo | - |
dc.contributor.author | Jang, Hyemin | - |
dc.contributor.author | Kwon, Hojeong | - |
dc.contributor.author | Lee, Hyejoo | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2021-11-21T06:40:30Z | - |
dc.date.available | 2021-11-21T06:40:30Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-04-27 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128204 | - |
dc.description.abstract | Objective We investigated the frequency of beta-amyloid (A beta) positivity in 9 groups classified according to a combination of 3 different cognition states and 3 distinct levels of white matter hyperintensities (WMH) (minimal, moderate, and severe) and aimed to determine which factors were associated with A beta after controlling for WMH and vice versa. Methods A total of 1,047 individuals with subjective cognitive decline (SCD, n = 294), mild cognitive impairment (MCI, n = 237), or dementia (n = 516) who underwent A beta PET scans were recruited from the memory clinic at Samsung Medical Center in Seoul, Korea. We investigated the following: (1) A beta positivity in the 9 groups, (2) the relationship between A beta positivity and WMH severity, and (3) clinical and genetic factors independently associated with A beta or WMH. Results A beta positivity increased as the severity of cognitive impairment increased (SCD [15.7%], MCI [43.5%], and dementia [76.2%]), whereas it decreased as the severity of WMH increased (minimal [54.5%], moderate [53.9%], and severe [41.0%]) or the number of lacunes (0 [59.0%], 1-3 [42.0%], and >3 [23.4%]) increased. A beta positivity was associated with higher education, absence of diabetes, and presence of APOE epsilon 4 after controlling for cognitive and WMH status. Conclusion Our analysis of A beta positivity involving a large sample classified according to the stratified cognitive states and WMH severity indicates that Alzheimer and cerebral small vessel diseases lie on a continuum. Our results offer clinicians insightful information about the association among A beta, WMH, and cognition. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | WHITE-MATTER HYPERINTENSITIES | - |
dc.subject | SMALL-VESSEL DISEASE | - |
dc.subject | MILD COGNITIVE IMPAIRMENT | - |
dc.subject | ALZHEIMER-DISEASE | - |
dc.subject | DEMENTIA | - |
dc.subject | BURDEN | - |
dc.subject | BETA | - |
dc.subject | BIOMARKERS | - |
dc.subject | PATHOLOGY | - |
dc.subject | ISCHEMIA | - |
dc.title | Amyloid Positivity in the Alzheimer/Subcortical-Vascular Spectrum | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Sung Hoon | - |
dc.identifier.doi | 10.1212/WNL.0000000000011833 | - |
dc.identifier.scopusid | 2-s2.0-85105763895 | - |
dc.identifier.wosid | 000658823300027 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.96, no.17, pp.E2201 - E2211 | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 96 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | E2201 | - |
dc.citation.endPage | E2211 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | WHITE-MATTER HYPERINTENSITIES | - |
dc.subject.keywordPlus | SMALL-VESSEL DISEASE | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | ALZHEIMER-DISEASE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | BURDEN | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | ISCHEMIA | - |
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