Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Mihyun | - |
dc.contributor.author | Kim, Seong-Woo | - |
dc.contributor.author | Ahn, Somin | - |
dc.contributor.author | Vu, Thi Que Anh | - |
dc.contributor.author | Yun, Cheolmin | - |
dc.contributor.author | Kim, Yong Yeon | - |
dc.date.accessioned | 2021-11-21T09:40:57Z | - |
dc.date.available | 2021-11-21T09:40:57Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-04-20 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128220 | - |
dc.description.abstract | The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs' eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The spectral-domain OCTA device was set to scan an area of 8.8x4.4 mm (30 degrees x15 degrees) above the optic nerve head for each IOP. The relative vessel density (rVAD) compared to baseline was determined for the total retinal blood flow (RBF) which included major retinal artery and venous vessels, radial peripapillary capillaries (RPCs), superficial (SVP), intermediate (IVP), and deep vascular plexus (DVP). The mean rVAD was 0.890 in RBF, 0.826 in RPCs, 0.817 in SVP, 0.819 in IVP, and 0.794 in DVP at 30 mmHg. While the rVAD of RBF and RPCs decreased to 0.504 and 0.541 at 45 mmHg, the SVP, IVP, and DVP decreased to 0.433, 0.359, and 0.345, respectively. When IOP was normalized, the rVAD was recovered in all layers and the VAD of RBF, IVP, and DVP were higher than baseline (P=0.040, 0.019, and 0.019, respectively). Retinal capillary density deterioration in each layer was found from 30 mmHg using an OCTA system which showed excellent depth-resolved segmentation of retinal capillary layers even at higher IOPs. Reduction in VAD showed full recovery after IOP normalization. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seong-Woo | - |
dc.contributor.affiliatedAuthor | Kim, Yong Yeon | - |
dc.identifier.doi | 10.1038/s41598-021-87689-8 | - |
dc.identifier.scopusid | 2-s2.0-85104654671 | - |
dc.identifier.wosid | 000642521600005 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.