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All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

Authors
Lee, Jung MinLin, DingchangKim, Ha-ReemPyo, Young-WooHong, GuosongLieber, Charles M.Park, Hong-Gyu
Issue Date
14-4월-2021
Publisher
AMER CHEMICAL SOC
Keywords
optogenetics; injectable mesh electronics; flexible waveguide; biocompatible optogenetic probes; chronic neural interface
Citation
NANO LETTERS, v.21, no.7, pp.3184 - 3190
Indexed
SCIE
SCOPUS
Journal Title
NANO LETTERS
Volume
21
Number
7
Start Page
3184
End Page
3190
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128239
DOI
10.1021/acs.nanolett.1c00425
ISSN
1530-6984
Abstract
The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.
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