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Structure elucidation of a new triterpene fromInonotus obliquus
- Issue Date
- 4월-2021
- Publisher
- WILEY
- Keywords
- anti-inflammatory; Inonotus obliquus; lanostane-type triterpene
- Citation
- MAGNETIC RESONANCE IN CHEMISTRY, v.59, no.4, pp.489 - 494
- Indexed
- SCIE
SCOPUS
- Journal Title
- MAGNETIC RESONANCE IN CHEMISTRY
- Volume
- 59
- Number
- 4
- Start Page
- 489
- End Page
- 494
- ISSN
- 0749-1581
- Abstract
- Ethyl acetate (EtOAc) fraction of theInonotus obliquus(Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds2-4significantly reduced LPS-induced nitric oxide production to 4.5 +/- 0.8%, 47.4 +/- 4.4%, and 2.8 +/- 1.7%, respectively, at a concentration of 30 mu M.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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