UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Min Ji | - |
dc.contributor.author | Choi, Boyoon | - |
dc.contributor.author | Kim, Eun Jin | - |
dc.contributor.author | Ohk, Jiyeon | - |
dc.contributor.author | Yang, Chansik | - |
dc.contributor.author | Choi, Yeon-Gil | - |
dc.contributor.author | Lee, Jinyoung | - |
dc.contributor.author | Kang, Chanhee | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.contributor.author | Woo, Jae-Sung | - |
dc.contributor.author | Cho, Yongcheol | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.contributor.author | Jung, Hosung | - |
dc.contributor.author | Kim, Chungho | - |
dc.date.accessioned | 2021-11-22T17:40:43Z | - |
dc.date.available | 2021-11-22T17:40:43Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-03-29 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128380 | - |
dc.description.abstract | p62/SQSTM1 is known to act as a key mediator in the selective autophagy of protein aggregates, or aggrephagy, by steering ubiquitinated protein aggregates towards the autophagy pathway. Here, we use a yeast two-hybrid screen to identify the prefoldin-like chaperone UXT as an interacting protein of p62. We show that UXT can bind to protein aggregates as well as the LB domain of p62, and, possibly by forming an oligomer, increase p62 clustering for its efficient targeting to protein aggregates, thereby promoting the formation of the p62 body and clearance of its cargo via autophagy. We also find that ectopic expression of human UXT delays SOD1(A4V)-induced degeneration of motor neurons in a Xenopus model system, and that specific disruption of the interaction between UXT and p62 suppresses UXT-mediated protection. Together, these results indicate that UXT functions as an autophagy adaptor of p62-dependent aggrephagy. Furthermore, our study illustrates a cooperative relationship between molecular chaperones and the aggrephagy machinery that efficiently removes misfolded protein aggregates. p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression delays motor neuron degeneration in a Xenopus model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.contributor.affiliatedAuthor | Woo, Jae-Sung | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.contributor.affiliatedAuthor | Kim, Chungho | - |
dc.identifier.doi | 10.1038/s41467-021-22252-7 | - |
dc.identifier.scopusid | 2-s2.0-85103585447 | - |
dc.identifier.wosid | 000636294300002 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SELECTIVE AUTOPHAGY | - |
dc.subject.keywordPlus | AGGREGATED PROTEINS | - |
dc.subject.keywordPlus | MUTANT SOD1 | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | P62/SQSTM1 | - |
dc.subject.keywordPlus | PREFOLDIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SQSTM1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.