Association of Inflammatory Metabolic Activity of Psoas Muscle and Acute Myocardial Infarction: A Preliminary Observational Study with F-18-FDG PET/CT
- Authors
- Pahk, Kisoo; Kim, Eung Ju; Kwon, Hyun Woo; Joung, Chanmin; Seo, Hong Seog; Kim, Sungeun
- Issue Date
- 3월-2021
- Publisher
- MDPI
- Keywords
- coronary artery disease; acute myocardial infarction; psoas muscle; inflammation; atherosclerosis; positron-emission tomography
- Citation
- DIAGNOSTICS, v.11, no.3
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIAGNOSTICS
- Volume
- 11
- Number
- 3
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128453
- DOI
- 10.3390/diagnostics11030511
- ISSN
- 2075-4418
- Abstract
- Inflamed skeletal muscle promotes chronic inflammation in atherosclerotic plaques, thereby contributing to the increased risk of coronary artery disease (CAD). In this study, we evaluated the metabolic activity of psoas muscle, using F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), and its association with carotid artery inflammation and acute myocardial infarction (AMI). In total, 90 participants (32 AMI, 33 chronic stable angina (CSA), and 25 control) were enrolled in this prospective study. Metabolic activity of skeletal muscle (SM) was measured by using maximum standardized uptake value (SUVmax) of psoas muscle, and corresponding psoas muscle area (SM area) was also measured. Carotid artery inflammation was evaluated by using the target-to background ratio (TBR) of carotid artery. SM SUVmax was highest in AMI, intermediate in CSA, and lowest in control group. SM SUVmax was significantly correlated with carotid artery TBR and systemic inflammatory surrogate markers. Furthermore, SM SUVmax was independently associated with carotid artery TBR and showed better predictability than SM area for the prediction of AMI. Metabolic activity of psoas muscle assessed by F-18-FDG PET/CT was associated with coronary plaque vulnerability and synchronized with the carotid artery inflammation in the participants with CAD. Furthermore, it may also be useful to predict AMI.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.