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The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer?s Dementia: A Double-Blind Randomized Placebo-Controlled Trial

Authors
Youn, HyunChulLee, Kang JoonKim, Shin-GyeomCho, Seong-JinKim, Woo JungLee, Won JoonHwang, Jae YeonHan, ChangsuShin, CheolminJung, Han-yong
Issue Date
3월-2021
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Alzheimer?s dementia; Memantine; Acetylcholinesterase inhibitors; Behavioral and psychological symptoms of dementia; Disinhibition; Neuropsychiatric inventory
Citation
PSYCHIATRY INVESTIGATION, v.18, no.3, pp.233 - 240
Indexed
SCIE
SSCI
SCOPUS
KCI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
18
Number
3
Start Page
233
End Page
240
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128457
DOI
10.30773/pi.2020.0329
ISSN
1738-3684
Abstract
Objective This study aimed to investigate treatment effects of combination therapy of memantine and acetylcholinesterase inhibitors (AchEIs) compared with AchEIs alone on behavioral and psychological symptoms of dementia (BPSD) in patients with moderate Alzheimer?s dementia (AD). Methods This was a 12-week, double-blind, randomized, placebo-controlled trial. A total of 148 patients with moderate AD participated in this study. Mini-Mental State Examination, Neuropsychiatric Inventory (NPI), Clinician?s Interview-Based Impression of Change plus caregiver input, Gottfries?Br?ne?Steen Scale, and Zarit Burden Interview were used as assessment scales. Results There were no significant differences in age, sex, or education between AChEIs alone and combination groups. The combination group showed significantly more improvement of NPI-disinhibition score (0.76?2.15) than the AChEIs alone group (-0.14?1.71) after 12 weeks. Conclusion Our findings suggest that the combination therapy of memantine and AchEIs might be a beneficial option for reducing disinhibition symptoms of patients with moderate AD compared with AchEIs alone. We believe that clinicians need to consider additional memantine treatment when patients with moderate AD complain disinhibition symptom. A larger clinical trial is needed to further determine the efficacy and advantages of such combination therapy of memantine and AchEIs for treating BPSD of patients with moderate AD. Psychiatry Investig 2021;18(3):233-240 Key Words Alzheimer?s dementia, Memantine, Acetylcholinesterase inhibitors, Behavioral and psychological symptoms of dementia,
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