A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor
DC Field | Value | Language |
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dc.contributor.author | Jeon, Han Jo | - |
dc.contributor.author | Jeong, Seung | - |
dc.contributor.author | Choi, Hyuk Soon | - |
dc.contributor.author | Jang, Se Hyun | - |
dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Kim, Seung Han | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Kim, Eun Sun | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Lee, Hong Sik | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Chung, Jong Hoon | - |
dc.contributor.author | Kim, Seong Nam | - |
dc.date.accessioned | 2021-11-23T10:41:02Z | - |
dc.date.available | 2021-11-23T10:41:02Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128467 | - |
dc.description.abstract | Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview (R) (Poloxamer 188), Blue Eye (TM) (0.4% hyaluronic acid), and aqueous chitosan solution (2.0%) were injected into the submucosa of porcine stomachs ex vivo. The mucosal elevation height, elevated surface area, and angle of the tangent of the submucosal fluid cushion were measured using a three-dimensional sensor. The rates of change for each variable were calculated, and the correlation between parameters was analyzed. Tissue specimens were stained with hematoxylin and eosin. Results: All variables exhibited the highest values under chitosan injection. The mucosal elevation height rate of change differed significantly between normal saline and chitosan solution (p=0.024). The elevated surface area rates of change for normal saline and Eleview (R) were significantly different from those for TS-905 and chitosan solution (p=0.006 and p=0.009, respectively). Further, height, area, and angle showed a positive correlation (p<0.001). A histological examination revealed an even distribution of aqueous chitosan within the submucosa without tissue damage. Conclusions: Aqueous chitosan was superior to normal saline and Eleview (R) and was noninferior to TS-905. A three-dimensional sensor and the measured parameters were effective and useful for evaluating the performance of submucosal fluids. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.title | A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Hyuk Soon | - |
dc.contributor.affiliatedAuthor | Kim, Seung Han | - |
dc.contributor.affiliatedAuthor | Lee, Jae Min | - |
dc.contributor.affiliatedAuthor | Keum, Bora | - |
dc.contributor.affiliatedAuthor | Jeen, Yoon Tae | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.identifier.doi | 10.5009/gnl19383 | - |
dc.identifier.scopusid | 2-s2.0-85102964727 | - |
dc.identifier.wosid | 000629332600007 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.15, no.2, pp.217 - 224 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 224 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002694444 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ENDOSCOPIC MUCOSAL RESECTION | - |
dc.subject.keywordPlus | PHOTOCROSSLINKABLE CHITOSAN | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordPlus | DISSECTION | - |
dc.subject.keywordAuthor | Endoscopy | - |
dc.subject.keywordAuthor | gastrointestinal | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Stomach | - |
dc.subject.keywordAuthor | Injections | - |
dc.subject.keywordAuthor | Imaging | - |
dc.subject.keywordAuthor | three-dimensional | - |
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