Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Comparison of the efficacy and safety of biological agents in patients with systemic juvenile idiopathic arthritis: A Bayesian network meta-analysis of randomized controlled trials

Full metadata record
DC Field Value Language
dc.contributor.authorSong, Gwan Gyu-
dc.contributor.authorLee, Young Ho-
dc.date.accessioned2021-11-23T17:40:54Z-
dc.date.available2021-11-23T17:40:54Z-
dc.date.created2021-08-30-
dc.date.issued2021-03-
dc.identifier.issn0946-1965-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/128501-
dc.description.abstractObjective: To assess the relative efficacy and safety of biological agents in patients with systemic juvenile idiopathic arthritis (sJIA). Materials and methods: We performed a Bayesian network meta-analysis to combine direct and indirect evidence from randomized controlled trials (RCTs) to examine the efficacy and safety of canakinumab, anakinra, tocilizumab, and rilonacept in patients with sJIA. Results: Five RCTs that included 286 patients met the inclusion criteria. Canakinumab was the most effective treatment for sJIA (odds ratio, 55.04; 95% credible interval, 15.52 - 253.29). A greater efficacy was observed with canakinumab than with tocilizumab and rilonacept. All interventions achieved a significant modified American College of Rheumatology Pediatric 30 (ACRpedi30) response compared to the placebo. The ranking probability, based on the surface under the cumulative ranking curve, indicated that canakinumab had the highest probability of being the best treatment in terms of the modified ACRpedi30 response rate, followed by anakinra, tocilizumab, rilonacept, and the placebo. However, no significant differences were observed in the incidence of serious adverse events after treatment with canakinumab, anakinra, tocilizumab, rilonacept, or the placebo. Conclusion: In patients with sJIA, canakinumab had the highest probability of being the best treatment in terms of the modified ACRpedi30 response rate; neither of the tested biological agents were associated with a significant risk of serious adverse events.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherDUSTRI-VERLAG DR KARL FEISTLE-
dc.subjectPLACEBO-CONTROLLED TRIAL-
dc.subjectRHEUMATOID-ARTHRITIS-
dc.subjectDOUBLE-BLIND-
dc.subjectASSOCIATIONS-
dc.subjectCANAKINUMAB-
dc.subjectRILONACEPT-
dc.titleComparison of the efficacy and safety of biological agents in patients with systemic juvenile idiopathic arthritis: A Bayesian network meta-analysis of randomized controlled trials-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Young Ho-
dc.identifier.doi10.5414/CP203791-
dc.identifier.scopusid2-s2.0-85102776292-
dc.identifier.wosid000628745200009-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, v.59, no.3, pp.239 - 246-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS-
dc.citation.titleINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS-
dc.citation.volume59-
dc.citation.number3-
dc.citation.startPage239-
dc.citation.endPage246-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusPLACEBO-CONTROLLED TRIAL-
dc.subject.keywordPlusRHEUMATOID-ARTHRITIS-
dc.subject.keywordPlusDOUBLE-BLIND-
dc.subject.keywordPlusASSOCIATIONS-
dc.subject.keywordPlusCANAKINUMAB-
dc.subject.keywordPlusRILONACEPT-
dc.subject.keywordAuthorsystemic juvenile-
dc.subject.keywordAuthoridiopathic arthritis-
dc.subject.keywordAuthorbiological agents-
dc.subject.keywordAuthorcanakinumab-
dc.subject.keywordAuthornetwork meta-analysis-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Young Ho photo

Lee, Young Ho
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE