A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice
DC Field | Value | Language |
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dc.contributor.author | Min, Hye Sook | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Ghee, Jung Yeon | - |
dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Cha, Jin Joo | - |
dc.contributor.author | Han, Jee Young | - |
dc.contributor.author | Han, Sang Youb | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.date.accessioned | 2021-11-23T21:40:57Z | - |
dc.date.available | 2021-11-23T21:40:57Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0024-3019 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128522 | - |
dc.description.abstract | Cyclosporine A (CyA) is an immunosuppressive agent that induces nephrotoxicity with long-term treatment. The roles of DPP-4 and its inhibitors in cyclosporine nephrotoxicity are not fully understood. Therefore, we investigated the effects of a novel DPP-4 inhibitor, DA-1229, on the progression of renal disease in an experimental cyclosporine nephrotoxicity model. Chronic cyclosporine nephrotoxicity was induced in six-week-old male ICR mice by subcutaneous injections of CyA at a dose of 30 mg/kg for four weeks. Animals were treated with DA-1229 at a dose of 300 mg/kg per day in food for four weeks. Although DPP-4 activity did not increase in the kidneys of mice with induced cyclosporine nephrotoxicity, DA-1229 treatment significantly suppressed DPP-4 activity in both plasma and renal tissues. DPP-4 inhibition by DA-1229 led to significantly decreased albuminuria and urinary excretion of 8-isoprosatane. DPP-4 inhibition also substantially suppressed pro-inflammatory effects, profibrotic molecules, and macrophage infiltration, and led to the improvement in renal structural changes. Our results suggest that DPP-4 inhibition by DA-1229 provides renoprotective effects in an animal model of cyclosporine nephrotoxicity via antioxidant, anti-inflammatory, and anti-fibrotic mechanisms. DPP-4 inhibition may be a useful new therapeutic approach for the management of progressive renal disease in cyclosporine nephrotoxicity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Dae Ryong | - |
dc.identifier.doi | 10.3390/life11030251 | - |
dc.identifier.scopusid | 2-s2.0-85103507074 | - |
dc.identifier.wosid | 000633842800001 | - |
dc.identifier.bibliographicCitation | LIFE-BASEL, v.11, no.3, pp.na | - |
dc.relation.isPartOf | LIFE-BASEL | - |
dc.citation.title | LIFE-BASEL | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | na | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordAuthor | cyclosporine nephrotoxicity | - |
dc.subject.keywordAuthor | DPP-4 | - |
dc.subject.keywordAuthor | DA-1229 | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | fibrosis | - |
dc.subject.keywordAuthor | oxidative stress | - |
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