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Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, D.Y. | - |
| dc.contributor.author | Kim, H.J. | - |
| dc.date.accessioned | 2021-12-01T21:41:59Z | - |
| dc.date.available | 2021-12-01T21:41:59Z | - |
| dc.date.created | 2021-08-31 | - |
| dc.date.issued | 2021-07-02 | - |
| dc.identifier.issn | 1523-7060 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128721 | - |
| dc.description.abstract | The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections. © | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | American Chemical Society | - |
| dc.title | Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Kim, H.J. | - |
| dc.identifier.doi | 10.1021/acs.orglett.1c01786 | - |
| dc.identifier.scopusid | 2-s2.0-85110173023 | - |
| dc.identifier.wosid | 000670661700062 | - |
| dc.identifier.bibliographicCitation | Organic Letters, v.23, no.13, pp.5256 - 5260 | - |
| dc.relation.isPartOf | Organic Letters | - |
| dc.citation.title | Organic Letters | - |
| dc.citation.volume | 23 | - |
| dc.citation.number | 13 | - |
| dc.citation.startPage | 5256 | - |
| dc.citation.endPage | 5260 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | SIDEROMYCIN ANTIBIOTICS | - |
| dc.subject.keywordPlus | IRON ACQUISITION | - |
| dc.subject.keywordPlus | SIDEROPHORE | - |
| dc.subject.keywordPlus | BAUMANNII | - |
| dc.subject.keywordPlus | ENTEROBACTIN | - |
| dc.subject.keywordPlus | HYDROXAMATE | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.subject.keywordPlus | RESISTANCE | - |
| dc.subject.keywordPlus | THERAPY | - |
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