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Wide-range direct detection of 25-hydroxyvitamin D3 using polyethylene-glycol-free gold nanorod based on LSPR aptasensor

Authors
Jo, S.Lee, W.Park, J.Park, H.Kim, M.Kim, W.Hong, J.Park, J.
Issue Date
1-6월-2021
Publisher
Elsevier Ltd
Keywords
25-Hydroxyvitamin D3; Aptasensor; Localized surface plasmon resonance; PEG-Free gold nanorods; Surface modification
Citation
Biosensors and Bioelectronics, v.181
Indexed
SCIE
SCOPUS
Journal Title
Biosensors and Bioelectronics
Volume
181
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128793
DOI
10.1016/j.bios.2021.113118
ISSN
0956-5663
Abstract
Vitamin D is associated with various diseases such as obesity, digestive problems, osteoporosis, depression, and infections, which has emerged as an interest in public healthcare. Recently, vitamin D has received more attention because of the potential implication with coronavirus disease 2019. In this study, we developed a localized surface plasmon resonance (LSPR) aptasensor based on polyethylene-glycol(PEG)-free gold nanorods (AuNRs) for the wide-range and direct detection of 25-hydroxyvitamin D3. The surfactant on AuNRs was removed by exchanging with polystyrene sulfonate (PSS) instead of PEG then the PSS was exchanged with citrate. By exchanging the stabilizer of AuNRs from PEG to PEG-free (i.e., citrate), the sensing efficiency of LSPR aptasensor was significantly improved. Additionally, LSPR aptasensor was functionalized with aptamer and blocking agent to enhance the sensing performance. The LSPR aptasensor achieved the direct, highly sensitive, and selective detection of 25-hydroxyvitamin D3 over a wide concentration range (0.1–105 ng/mL), with a limit of detection of 0.1 ng/mL. This detection range included the concentration of vitamin D from deficiency to excess. The PEG-free AuNR-based LSPR aptasensor affords a new avenue for the development of robust sensing technology for vitamins. © 2021 Elsevier B.V.
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