Chemical structure of a novel heteroglycan polysaccharide isolated from the biomass of Ophiocordyceps Sobolifera
- Authors
- Tran, T.V.T.; Tran, V.K.; Ho, X.A.V.; Le, L.S.; Le, T.H.; Nguyen, T.H.C.; Nguyen, C.C.; Kim, S.Y.; Le, Q.V.
- Issue Date
- 15-5월-2021
- Publisher
- Elsevier B.V.
- Keywords
- Gas-liquid chromatography-mass spectrometry; Methylation; Molecular weight; Nuclear magnetic resonance spectroscopy; Ophiocordyceps sobolifera; Polysaccharide
- Citation
- Journal of Molecular Structure, v.1232
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Molecular Structure
- Volume
- 1232
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128869
- DOI
- 10.1016/j.molstruc.2021.129986
- ISSN
- 0022-2860
- Abstract
- This study aims at identifying the structure of polysaccharide (PS) extracted from the biomass of Vietnam-grown Ophiocordyceps sobolifera for the first time. The molecular weight of the obtained polysaccharide (denoted as PS-T100) is found to be 2.29 × 105 Da using gel permeation high-performance liquid chromatography. The structural investigations of the sample PS-T100 unveil a novel structure composed of a heteropolysaccharide with the appearance of two main sugars, D-glucose and D-mannose, in the backbone. Indeed, methylation analysis indicates that PS-T100 is mainly composed of (1→3)-linked glucosyl and (1→3)-linked mannosyl units. Moreover, 1D and 2D nuclear magnetic resonance spectroscopy interpretations of the sample PS-T100 prove the repeating unit of the isolated polysaccharide is [→3)-β-D-Glcp-(1→3)-α-D-Manp-(1→3)-β-D-Glcp-(1→3)-α-D-Manp-(1→3)-β-D-Glcp-(1→]n. Such a structure appears to be a novel polysaccharide. The obtained results contribute to enriching the database of Ophiocordyceps sobolifera- extracted PSs and open up a new pathway toward the production of PS-T100 for biomedical applications. © 2021 Elsevier B.V.
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