Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | Han Sang Youb | - |
dc.contributor.author | Jeong Kyung Hwan | - |
dc.contributor.author | Ihm Chun Gyoo | - |
dc.contributor.author | Kang Young Sun | - |
dc.contributor.author | 차대룡 | - |
dc.date.accessioned | 2021-12-03T16:42:19Z | - |
dc.date.available | 2021-12-03T16:42:19Z | - |
dc.date.created | 2021-08-31 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129163 | - |
dc.description.abstract | Background: Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropa thy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods: Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results: The levels of serum interferon-gamma (IFNγ) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly cor related with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFNγ, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients un dergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFNγ among representative Th1/Th2 cytokines. Conclusion: IFNγ was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an in crease in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한신장학회 | - |
dc.title | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of IgA nephropathy | - |
dc.title.alternative | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of IgA nephropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 차대룡 | - |
dc.identifier.doi | 10.23876/j.krcp.20.157 | - |
dc.identifier.scopusid | 2-s2.0-85104545996 | - |
dc.identifier.wosid | 000636459700009 | - |
dc.identifier.bibliographicCitation | Kidney Research and Clinical Practice, v.40, no.1, pp.69 - 76 | - |
dc.relation.isPartOf | Kidney Research and Clinical Practice | - |
dc.citation.title | Kidney Research and Clinical Practice | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 76 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002702920 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | HUMAN MESANGIAL CELLS | - |
dc.subject.keywordPlus | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | IGA NEPHROPATHY | - |
dc.subject.keywordPlus | TH1/TH2 PREDOMINANCE | - |
dc.subject.keywordPlus | CYTOKINES DETERMINE | - |
dc.subject.keywordPlus | RENAL-FUNCTION | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | PROTEIN-1 | - |
dc.subject.keywordAuthor | Chemokine CCL2 | - |
dc.subject.keywordAuthor | IGA glomerulonephritis | - |
dc.subject.keywordAuthor | Interferons | - |
dc.subject.keywordAuthor | T helper 1 cells | - |
dc.subject.keywordAuthor | T helper 2 cells | - |
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