Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
DC Field | Value | Language |
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dc.contributor.author | Chang, Yoonkyung | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.contributor.author | Kim, Min-Kyung | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.contributor.author | Oh, Kyungmi | - |
dc.date.accessioned | 2021-12-04T14:41:21Z | - |
dc.date.available | 2021-12-04T14:41:21Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-01-13 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129385 | - |
dc.description.abstract | Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term functional recovery after acute ischemic stroke in non-diabetic patients. Between May 2014 and December 2016, 1377 consecutive patients with acute ischemic stroke were enrolled from a prospectively maintained stroke registry. After excluding patients with transient ischemic attacks (TIA), pre-stroke disabilities, diabetes mellitus, and patients with incomplete evaluations, 517 patients were included in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to evaluate the degree of insulin resistance. The patients with the highest quartile of log HOMA-IR index scores were younger and had higher fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, and HbA1c levels. Multivariable logistic regression analysis revealed that log HOMA-IR scores were independently associated with poor prognosis after adjusting for age and sex and p<0.1 in univariable analysis. Insulin resistance was associated with the poor functional outcome of non-diabetic stroke patients. This evidence supports treating insulin resistance in acute ischemic stroke patients with blood glucose levels within the normal range. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chi Kyung | - |
dc.identifier.doi | 10.1038/s41598-020-80315-z | - |
dc.identifier.scopusid | 2-s2.0-85099251182 | - |
dc.identifier.wosid | 000621768900031 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
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