Radiation-induced IL-1 beta expression and secretion promote cancer cell migration/invasion via activation of the NF-kappa B-RIP1 pathway
DC Field | Value | Language |
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dc.contributor.author | Kang, A-Ram | - |
dc.contributor.author | Cho, Jeong Hyun | - |
dc.contributor.author | Lee, Na-Gyeong | - |
dc.contributor.author | Kwon, Jin-Hee | - |
dc.contributor.author | Song, Jie-Young | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.contributor.author | Jung, In Su | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Um, Hong-Duck | - |
dc.contributor.author | Oh, Sang Cheul | - |
dc.contributor.author | Park, Jong Kuk | - |
dc.date.accessioned | 2021-12-04T19:59:57Z | - |
dc.date.available | 2021-12-04T19:59:57Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-01-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129437 | - |
dc.description.abstract | Here, we demonstrate that interleukin-1 beta (IL-1 beta) contributes to the gamma-ionizing radiation (IR)-induced increase of migration/invasion in A549 lung cancer cells, and that this occurs via RIP1 upregulation. We initially observed that the protein expression and secreted concentration of IL-1 beta were increased upon exposure of A549 cells to IR. We then demonstrated that IR-induced IL-1 beta is located downstream of the NF-kappa B-RIP1 signaling pathway. Treatments with siRNA and specific pharmaceutical inhibitors of RIP1 and NF-kappa B suppressed the IR-induced increases in the protein expression and secreted concentration of IL-1 beta. IL-1R alpha, an antagonist of IL-1 beta, treatment suppressed the IR-induced epithelial-mesenchymal transition (EMT) and IR-induced invasion/migration in vitro. These results suggest that IL-1 beta could regulate IR-induced EMT. We also found that IR could induce the expression of IL-1 beta expression in vivo and that of IL-1 receptor (R) I/II in vitro and in vivo. The IR-induced increases in the protein levels of IL-1 RI/II and IL-1 beta suggest that an autocrine loop between IL-1 beta and IL-1 RI/II might play important roles in IR-induced EMT and migration/invasion. Based on these collective results, we propose that IR concomitantly activates NF-kappa B and RIP1 to trigger the NF-kappa B-RIP1-IL-1 beta-IL-1RI/II-EMT pathway, ultimately promoting metastasis. (c) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Radiation-induced IL-1 beta expression and secretion promote cancer cell migration/invasion via activation of the NF-kappa B-RIP1 pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Sang Cheul | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.10.057 | - |
dc.identifier.scopusid | 2-s2.0-85095764366 | - |
dc.identifier.wosid | 000614555200015 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.534, pp.973 - 979 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 534 | - |
dc.citation.startPage | 973 | - |
dc.citation.endPage | 979 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordAuthor | gamma-ionizing radiation | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordAuthor | RIP1 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
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