Gut Bacterial Dysbiosis in Children with Intractable Epilepsy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kihyun | - |
dc.contributor.author | Kim, Namil | - |
dc.contributor.author | Shim, Jung Ok | - |
dc.contributor.author | Kim, Gun-Ha | - |
dc.date.accessioned | 2021-12-05T01:00:05Z | - |
dc.date.available | 2021-12-05T01:00:05Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129487 | - |
dc.description.abstract | A few published clinical studies have evaluated the association between gut microbiota in intractable epilepsy, but with inconsistent results. We hypothesized that the factors associated with the gut bacterial composition, such as age and geography, contributed to the discrepancies. Therefore, we used a cohort that was designed to minimize the effects of possible confounding factors and compared the gut microbiota between children with intractable epilepsy and healthy controls. Eight children with intractable epilepsy aged 1 to 7 years and 32 age-matched healthy participants were included. We collected stool samples and questionnaires on their diet and bowel habits at two time points and analyzed the gut microbiota compositions. In the epilepsy group, the amount of Bacteroidetes was lower (Mann-Whitney test, false discovery rate (FDR) < 0.01) and the amount of Actinobacteria was higher (FDR < 0.01) than in the healthy group. The epilepsy subjects were 1.6- to 1.7-fold lower in microbiota richness indices (FDR < 0.01) and harbored a distinct species composition (p < 0.01) compared to the healthy controls. Species biomarkers for intractable epilepsy included the Enterococcus faecium group, Bifidobacterium longum group, and Eggerthella lenta, while the strongest functional biomarker was the ATP-binding cassette (ABC) transporter. Our study identified gut bacterial dysbiosis associated with intractable epilepsy within the cohort that was controlled for the factors that could affect the gut microbiota. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ANTIBIOTIC DRUGS | - |
dc.subject | MICROBIOTA | - |
dc.title | Gut Bacterial Dysbiosis in Children with Intractable Epilepsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jung Ok | - |
dc.identifier.doi | 10.3390/jcm10010005 | - |
dc.identifier.scopusid | 2-s2.0-85114068563 | - |
dc.identifier.wosid | 000606053700001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.10, no.1, pp.1 - 12 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ANTIBIOTIC DRUGS | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.subject.keywordAuthor | microbiome | - |
dc.subject.keywordAuthor | microbiota | - |
dc.subject.keywordAuthor | intestinal flora | - |
dc.subject.keywordAuthor | stool | - |
dc.subject.keywordAuthor | epilepsy | - |
dc.subject.keywordAuthor | ketogenic diet | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.