The Application of Mass Spectrometry in Drug Metabolism and Pharmacokinetics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji-Yoon | - |
dc.contributor.author | Kim, Sang Kyum | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Oh, Soo Jin | - |
dc.date.accessioned | 2021-12-07T12:41:21Z | - |
dc.date.available | 2021-12-07T12:41:21Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130085 | - |
dc.description.abstract | Drug metabolism and pharmacokinetics (DMPK) are fundamental in drug discovery. New chemical entities (NCEs) are typically evaluated with various in vitro and in vivo assays, which are time-consuming and labor intensive. These experiments are essential in identifying potential new drugs. Recently, mass spectrometry (MS) has played a key role in examining the drug-like properties of NCEs. Quantitative and qualitative mass spectrometry approaches are routinely utilized to obtain high-quality data in an efficient, timely, and cost-effective manner. Especially, liquid chromatography (LC) coupled with MS technology has been refined for metabolite identification (Met ID), which is critical for lead optimization. These qualitative and quantitative MS approaches and their specific utility in DMPK characterization will be described in this chapter. © 2021, Springer Nature Singapore Pte Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.subject | PRESSURE CHEMICAL-IONIZATION | - |
dc.subject | LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY | - |
dc.subject | DIFLUNISAL ACYL GLUCURONIDE | - |
dc.subject | HUMAN SERUM-ALBUMIN | - |
dc.subject | TIME-OF-FLIGHT | - |
dc.subject | IN-VITRO | - |
dc.subject | TRIPLE-QUADRUPOLE | - |
dc.subject | REACTIVE METABOLITES | - |
dc.subject | COVALENT BINDING | - |
dc.subject | ELECTROSPRAY-IONIZATION | - |
dc.title | The Application of Mass Spectrometry in Drug Metabolism and Pharmacokinetics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.identifier.doi | 10.1007/978-981-33-6064-8_20 | - |
dc.identifier.scopusid | 2-s2.0-85104120767 | - |
dc.identifier.wosid | 000647698100020 | - |
dc.identifier.bibliographicCitation | ADVANCED IMAGING AND BIO TECHNIQUES FOR CONVERGENCE SCIENCE, v.1310, pp.533 - 550 | - |
dc.relation.isPartOf | ADVANCED IMAGING AND BIO TECHNIQUES FOR CONVERGENCE SCIENCE | - |
dc.citation.title | ADVANCED IMAGING AND BIO TECHNIQUES FOR CONVERGENCE SCIENCE | - |
dc.citation.volume | 1310 | - |
dc.citation.startPage | 533 | - |
dc.citation.endPage | 550 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Book Chapter | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Microscopy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Microscopy | - |
dc.subject.keywordPlus | PRESSURE CHEMICAL-IONIZATION | - |
dc.subject.keywordPlus | LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY | - |
dc.subject.keywordPlus | DIFLUNISAL ACYL GLUCURONIDE | - |
dc.subject.keywordPlus | HUMAN SERUM-ALBUMIN | - |
dc.subject.keywordPlus | TIME-OF-FLIGHT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TRIPLE-QUADRUPOLE | - |
dc.subject.keywordPlus | REACTIVE METABOLITES | - |
dc.subject.keywordPlus | COVALENT BINDING | - |
dc.subject.keywordPlus | ELECTROSPRAY-IONIZATION | - |
dc.subject.keywordAuthor | Drug discovery | - |
dc.subject.keywordAuthor | Drug metabolism | - |
dc.subject.keywordAuthor | Mass spectrometry | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
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