Total Platelet Transcriptomics and Its Network Analysis by RNA-Seq and miRNA-Seq and PCA Application in Essential Thrombocythaemia
DC Field | Value | Language |
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dc.contributor.author | Moon, Kyung Chul | - |
dc.contributor.author | Gim, Jeong-An | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Yoon, Jung | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.date.accessioned | 2021-12-07T12:41:30Z | - |
dc.date.available | 2021-12-07T12:41:30Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130086 | - |
dc.description.abstract | Differentiating the aetiology of thrombocytosis is limited yet crucial in patients with essential thrombocythaemia (ET). MicroRNAs (miRNAs) regulate haematopoiesis and lineage commitment; aberrant expression of miRNAs plays an important role in myeloproliferative neoplasms. However, the miRNA profile has been poorly explored in ET patients compared to patients with reactive thrombocytosis (RT). A total of 9 samples, including 5 ET patient samples, 2 RT patient samples, and 2 healthy control samples, were analysed in this study. We produced 81.43 million reads from transcripts and 59.60 million reads from small RNAs. We generated a comprehensive miRNA-mRNA regulatory network and identified unique 14 miRNA expression patterns associated with ET. Among the 14 miRNAs, miR-1268a was downregulated in ET and showed an inverse correlation with its 8 putative target genes, including genes associated with thrombus formation and platelet activation (CDH6, EHD2, FUT1, KIF26A, LINC00346, PTPRN, SERF1A, and SLC6A9). Principal component analysis (PCA) showed ET and non-ET groups well clustered in space, suggesting each group had a distinctive expression pattern of mRNAs and miRNAs. These results suggest that the significant dysregulation of miR-1268a and its 8 target genes could be a unique expression of platelet mi-RNAs and miRNA/mRNA regulatory network in ET patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | ABERRANT EXPRESSION | - |
dc.subject | MICRORNA | - |
dc.subject | PATHWAY | - |
dc.subject | TOPHAT | - |
dc.subject | GENE | - |
dc.title | Total Platelet Transcriptomics and Its Network Analysis by RNA-Seq and miRNA-Seq and PCA Application in Essential Thrombocythaemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.contributor.affiliatedAuthor | Yoon, Jung | - |
dc.identifier.doi | 10.1159/000510459 | - |
dc.identifier.scopusid | 2-s2.0-85097075818 | - |
dc.identifier.wosid | 000593498900001 | - |
dc.identifier.bibliographicCitation | ACTA HAEMATOLOGICA, v.144, no.3, pp.337 - 344 | - |
dc.relation.isPartOf | ACTA HAEMATOLOGICA | - |
dc.citation.title | ACTA HAEMATOLOGICA | - |
dc.citation.volume | 144 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 337 | - |
dc.citation.endPage | 344 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | ABERRANT EXPRESSION | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TOPHAT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Essential thrombocythaemia | - |
dc.subject.keywordAuthor | Transcriptome | - |
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