Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer
DC Field | Value | Language |
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dc.contributor.author | Liu, Quan | - |
dc.contributor.author | Xie, Zhongjian | - |
dc.contributor.author | Qiu, Meng | - |
dc.contributor.author | Shim, Inseob | - |
dc.contributor.author | Yang, Yunlong | - |
dc.contributor.author | Xie, Sisi | - |
dc.contributor.author | Yang, Qinhe | - |
dc.contributor.author | Wang, Dou | - |
dc.contributor.author | Chen, Shiyou | - |
dc.contributor.author | Fan, Taojian | - |
dc.contributor.author | Ding, Bo | - |
dc.contributor.author | Guo, Ziheng | - |
dc.contributor.author | Adah, Dickson | - |
dc.contributor.author | Yao, Xinhuang | - |
dc.contributor.author | Zhang, Yuhua | - |
dc.contributor.author | Wu, Hong | - |
dc.contributor.author | Wu, Zongze | - |
dc.contributor.author | Wei, Chaoying | - |
dc.contributor.author | Wang, Hongzhong | - |
dc.contributor.author | Kim, Hyeong Seok | - |
dc.contributor.author | Zou, Qingshuang | - |
dc.contributor.author | Yan, Qiaoting | - |
dc.contributor.author | Cai, Zhen | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Liu, Li-Ping | - |
dc.contributor.author | Zhang, Han | - |
dc.contributor.author | Cao, Yihai | - |
dc.date.accessioned | 2021-12-08T11:41:20Z | - |
dc.date.available | 2021-12-08T11:41:20Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130315 | - |
dc.description.abstract | Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | METAL-ORGANIC FRAMEWORKS | - |
dc.subject | DRUG-RELEASE | - |
dc.subject | MXENE | - |
dc.subject | DELIVERY | - |
dc.subject | TISSUE | - |
dc.title | Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1002/advs.202001191 | - |
dc.identifier.scopusid | 2-s2.0-85096802131 | - |
dc.identifier.wosid | 000585422900001 | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, v.7, no.24 | - |
dc.relation.isPartOf | ADVANCED SCIENCE | - |
dc.citation.title | ADVANCED SCIENCE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 24 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | METAL-ORGANIC FRAMEWORKS | - |
dc.subject.keywordPlus | DRUG-RELEASE | - |
dc.subject.keywordPlus | MXENE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | prodrug | - |
dc.subject.keywordAuthor | zirconium carbide | - |
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