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Photoluminescent Response of Poly(3-methylthiophene)-DNA Single Nanowire Correlating to Nucleotide-Mismatch Locus in DNA-DNA Hybridization

Authors
Park, Dong HyukCui, ChunzhiAhn, Dong June
Issue Date
11월-2020
Publisher
WILEY-V C H VERLAG GMBH
Keywords
pi-conjugated polymers; DNA; photoluminescence; poly(3-methylthiophene)
Citation
MACROMOLECULAR RAPID COMMUNICATIONS, v.41, no.21
Indexed
SCIE
SCOPUS
Journal Title
MACROMOLECULAR RAPID COMMUNICATIONS
Volume
41
Number
21
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/130417
DOI
10.1002/marc.202000164
ISSN
1022-1336
Abstract
pi-Conjugated polymers have become qualified candidates for biosensing owing to their unique optoelectronic properties and excellent biocompatibility. In this contribution, nucleotide mismatches in DNA hybridization, being variable in position, are reflected in a stark manner by poly(3-methylthiophene) (P3MT) nanowires (NWs), in which probe DNA sequence is properly functionalized. Selected as the systematic investigation are complementary target DNA (tDNA), random sequence DNA, and three kinds of 1-mer mismatched tDNAs with different mismatch loci away from the NW's surface. Nanoscale optical observation of the single P3MT NWs in solid states reveals that the more distant the mismatch position is from the surface, the higher the photoluminescence (PL) occurs, while the complementary sequence yields the highest but the random one remains the lowest. Hence, the PL intensity increases with the relative length of the DNA-DNA hybridization from the surface. These results deliver a new basis that pi-conjugated polymers can be potentially applicable to detailed nucleotide analyses as in single nucleotide polymorphism.
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공과대학 (화공생명공학과)
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