The platelet-to-lymphocyte ratio as a significant prognostic factor to predict survival outcomes in patients with synchronous metastatic renal cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuk, Hyeong Dong | - |
dc.contributor.author | Kang, Minyong | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Jeong, Chang Wook | - |
dc.contributor.author | Song, Cheryn | - |
dc.contributor.author | Seo, Seong Il | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Lee, Hakmin | - |
dc.date.accessioned | 2021-12-09T04:42:05Z | - |
dc.date.available | 2021-12-09T04:42:05Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2466-0493 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130488 | - |
dc.description.abstract | Purpose: The clinical impact of the platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with metastatic renal cell carcinoma (mRCC) remains controversial. We investigated the associations between elevation of the PLR and disease prognosis in patients with synchronous mRCC. Materials and Methods: The data of 1,505 patients with synchronous mRCC were retrospectively analyzed. The entire cohort was stratified into two subgroups according to PLR. Kaplan-Meier and Cox proportional analyses were performed to investigate the possible associations between the PLR and disease prognosis. Results: There were 921 patients with a high PLR and 584 patients with a low PLR by use of the cutoff of 146. The patients with a high PLR had worse clinical characteristics in terms of advanced clinical stage (p<0.001) and rate of lymph node invasion (p=0.036). The Kaplan-Meier analysis showed that patients with a high PLR had significantly shorter overall survival (OS) (p<0.001) and cancer-specific survival (CSS) (p<0.001). The multivariate Cox analysis revealed that the PLR was an independent predictor for shorter OS (hazard ratio [HR], 1.345; 95% confidence interval [Cl], 1.183-1.530; p<0.001) and CSS (HR, 1.318; 95% CI, 1.156-1.502; p<0.001). In the subgroup analyses, the PLR showed a significant association with survival outcomes in the subgroup with clear cell type (all p<0.05) but not in the subgroup with the non-clear cell type. Conclusions: The PLR was an independent prognostic factor for survival outcomes in patients with mRCC. However, the association was statistically significant only in patients with clear cell type mRCC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN UROLOGICAL ASSOC | - |
dc.subject | CANCER | - |
dc.subject | COUNT | - |
dc.subject | LUNG | - |
dc.subject | THROMBOCYTOSIS | - |
dc.subject | RISK | - |
dc.title | The platelet-to-lymphocyte ratio as a significant prognostic factor to predict survival outcomes in patients with synchronous metastatic renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jae Young | - |
dc.identifier.doi | 10.4111/icu.20200002 | - |
dc.identifier.scopusid | 2-s2.0-85090173926 | - |
dc.identifier.wosid | 000564609600003 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE AND CLINICAL UROLOGY, v.61, no.5, pp.475 - 481 | - |
dc.relation.isPartOf | INVESTIGATIVE AND CLINICAL UROLOGY | - |
dc.citation.title | INVESTIGATIVE AND CLINICAL UROLOGY | - |
dc.citation.volume | 61 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 475 | - |
dc.citation.endPage | 481 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002623905 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COUNT | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | THROMBOCYTOSIS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Blood platelets | - |
dc.subject.keywordAuthor | Kidney neoplasms | - |
dc.subject.keywordAuthor | Lymphocytes | - |
dc.subject.keywordAuthor | Neoplasm metastasis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.