Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients
DC Field | Value | Language |
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dc.contributor.author | Jung, Hee-Yeon | - |
dc.contributor.author | Seo, Min Young | - |
dc.contributor.author | Jeon, Yena | - |
dc.contributor.author | Huh, Kyu Ha | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Jung, Cheol Woong | - |
dc.contributor.author | Lee, Sik | - |
dc.contributor.author | Han, Seung-Yeup | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Choi, Ji-Young | - |
dc.contributor.author | Cho, Jang-Hee | - |
dc.contributor.author | Park, Sun-Hee | - |
dc.contributor.author | Kim, Yong-Lim | - |
dc.contributor.author | Kim, Chan-Duck | - |
dc.date.accessioned | 2021-12-09T15:00:32Z | - |
dc.date.available | 2021-12-09T15:00:32Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2020-07-02 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130587 | - |
dc.description.abstract | Background Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of 1-year post-transplant TAC trough levels on long-term renal and cardiovascular outcomes and opportunistic infections in stable KTRs. Methods KTRs receiving TAC with mycophenolate-based immunosuppression who did not experience renal or cardiovascular outcomes within 1 year post-transplant were enrolled from a multicenter observational cohort study. Renal outcome was defined as a composite of biopsy-proven acute rejection, interstitial fibrosis and tubular atrophy, and death-censored graft loss. Cardiovascular outcome was defined as a composite of de novo cardiomegaly, left ventricular hypertrophy, and cardiovascular events. Opportunistic infections were defined as the occurrence of BK virus or cytomegalovirus infections. Results A total of 603 eligible KTRs were divided into the low-level TAC (LL-TAC) and high-level TAC (HL-TAC) groups based on a median TAC level of 5.9 ng/mL (range 1.3-14.3) at 1 year post-transplant. The HL-TAC group had significantly higher TAC trough levels at 2, 3, 4, and 5 years compared with the levels of the LL-TAC group. During the mean follow-up of 63.7 +/- 13.0 months, there were 121 renal outcomes and 224 cardiovascular outcomes. In multivariate Cox regression analysis, LL-TAC and HL-TAC were not independent risk factors for renal and cardiovascular outcomes, respectively. No significant differences in the development of opportunistic infections and de novo donor-specific anti-human leukocyte antigen antibodies and renal allograft function were observed between the two groups. Conclusions TAC trough levels after 1 year post-transplant remained at a similar level until the fifth year after kidney transplantation and were not directly associated with long-term outcomes in stable Korean KTRs who did not experience renal or cardiovascular outcomes. Therefore, in Asian KTRs with a stable clinical course, TAC trough levels higher than approximately 6 ng/mL might not be required after a year of kidney transplantation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | EXTENDED-RELEASE TACROLIMUS | - |
dc.subject | ACUTE REJECTION | - |
dc.subject | RISK | - |
dc.subject | DISEASE | - |
dc.subject | NEPHROPATHY | - |
dc.subject | MORTALITY | - |
dc.subject | FAILURE | - |
dc.subject | IMPACT | - |
dc.title | Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Cheol Woong | - |
dc.identifier.doi | 10.1371/journal.pone.0235418 | - |
dc.identifier.scopusid | 2-s2.0-85087643936 | - |
dc.identifier.wosid | 000549913100039 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.15, no.7 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | EXTENDED-RELEASE TACROLIMUS | - |
dc.subject.keywordPlus | ACUTE REJECTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | IMPACT | - |
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