Potassium levels after liver reperfusion in adult patients undergoing cadaveric liver transplantation: A retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Weinberg, Laurence | - |
dc.contributor.author | Lee, Dong-Kyu | - |
dc.contributor.author | Koshy, Anoop Ninan | - |
dc.contributor.author | Leong, Kai Wen | - |
dc.contributor.author | Tosif, Shervin | - |
dc.contributor.author | Shaylor, Ruth | - |
dc.contributor.author | Pillai, Param | - |
dc.contributor.author | Miles, Lachlan Fraser | - |
dc.contributor.author | Drucker, Alexandra | - |
dc.contributor.author | Pearce, Brett | - |
dc.date.accessioned | 2021-12-09T15:41:30Z | - |
dc.date.available | 2021-12-09T15:41:30Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2049-0801 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130596 | - |
dc.description.abstract | Background: Hyperkalemia is a common cause of arrhythmias in patients undergoing liver transplantation. We examined the pattern of change of potassium levels during and immediately after reperfusion of the donor liver. Materials and methods: Potassium levels of 30 consecutive adult patients undergoing cadaveric liver transplantation were assessed before and after liver reperfusion. Changes in potassium levels over 13 predefined time-points were analyzed. Primary aim: to describe the pattern of change of potassium levels during the reperfusion period. Correlation between changes in potassium levels during reperfusion and a-priori variables were investigated. Results: Baseline median (IQR) potassium levels were 4.1 (3.8:4.5) mmol/L. Thirteen patients (43%) developed hyperkalemia, 10 (33%) of whom developed severe hyperkalemia. Potassium levels peaked at 80 s post re-perfusion, plateaued until 2 min, before returning toward baseline values at 5 min. There was a strong association between pre-reperfusion/baseline potassium levels and peak potassium values during reperfusion (95%CI: 0.26 to 0.77, p < 0.001). A baseline potassium level of 4.45 mmol/L was a good predictor of re-perfusion hyperkalemia with a sensitivity of 69.2% and specificity of 94.1% (AUC = 0.894, 95%CI: 0.779 to 1.000, p < 0.001). Conclusion: Hyperkalemia during cadaveric liver transplantation is common affecting almost 1 in 2 patients during reperfusion. During reperfusion potassium levels peaked within 2 min and over a third of patients developed severe hyperkalemia. Higher peak potassium levels correlated strongly with higher pre-reperfusion potassium values. These findings guide clinicians with timing of sampling of blood to check for hyperkalemia and identify modifiable factors associated with the development of hyperkalemia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | SERUM POTASSIUM | - |
dc.subject | HYPERKALEMIA | - |
dc.subject | ANESTHESIA | - |
dc.title | Potassium levels after liver reperfusion in adult patients undergoing cadaveric liver transplantation: A retrospective cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Kyu | - |
dc.identifier.doi | 10.1016/j.amsu.2020.05.002 | - |
dc.identifier.scopusid | 2-s2.0-85085031618 | - |
dc.identifier.wosid | 000544101300027 | - |
dc.identifier.bibliographicCitation | ANNALS OF MEDICINE AND SURGERY, v.55, pp.111 - 118 | - |
dc.relation.isPartOf | ANNALS OF MEDICINE AND SURGERY | - |
dc.citation.title | ANNALS OF MEDICINE AND SURGERY | - |
dc.citation.volume | 55 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 118 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SERUM POTASSIUM | - |
dc.subject.keywordPlus | HYPERKALEMIA | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordAuthor | Liver transplantation | - |
dc.subject.keywordAuthor | Potassium | - |
dc.subject.keywordAuthor | Reperfusion | - |
dc.subject.keywordAuthor | Anesthesia | - |
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